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We present here a typical case of EGPA in which treatment with IL\u20105 pathway inhibitors is prescribed, showing to be beneficial for the patient. We discuss available evidence proving the association between IL\u20105 and clinical activity in EGPA and review the clinical efficacy and safety of currently approved IL\u20105 pathway inhibitors (i.e.\u00a0mepolizumab and benralizumab) that improve disease control, reduce relapse rates, and have significant glucocorticoid\u2010sparing effects in EGPA by reducing eosinophilic inflammation.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/art.43409","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:28:59Z","timestamp":1760599739000},"page":"1196-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interleukin\u20105, Eosinophils, and Interleukin\u20105 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis"],"prefix":"10.1002","volume":"78","author":[{"given":"Alvise","family":"Berti","sequence":"first","affiliation":[{"name":"Unit of Rheumatology, S. 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