{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:42:08Z","timestamp":1790890928732,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2702000"],"award-info":[{"award-number":["2021YFC2702000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The therapeutic effects of telitacicept combined with standard of care (SoC) in childhood\u2010onset systemic lupus erythematosus (cSLE) remain unclear. This study aims to evaluate its efficacy in comparison with belimumab combined with SoC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective cohort study across seven tertiary hospitals in China, enrolling patients aged 5 to 18 years with cSLE. Primary endpoints included the proportions of patients attaining Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) at 3, 6, and 12 months after treatment, complemented by relapse rates and steroid tapering metrics. Propensity score\u2013based inverse probability of treatment weighting (IPTW) was employed to address baseline imbalances between the telitacicept group (n = 60) and the historical control group treated with belimumab (n = 67).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 60 enrolled patients (median follow\u2010up 12 [interquartile range 6\u201312] months), LLDAS and DORIS achievement rates progressively increased from 19.6% and 7.8% at 6 months to 65.7% and 37.1% at 12 months. Flare rates remained low (3 months: 1.7%; 6 months: 11.8%; 12 months: 14.3%). Notably, 74.3% of patients achieved prednisone doses \u22647.5 mg\/day by 12 months (vs baseline 13.3%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). IPTW\u2010adjusted analyses demonstrated comparable efficacy between the telitacicept and belimumab groups across all endpoints in terms of LLDAS and DORIS attainment, steroid reduction, and immunologic normalization (all\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Telitacicept combined with SoC exhibited significant improvements in disease activity, steroid reduction, and immunologic markers, with therapeutic outcomes comparable to belimumab in cSLE management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43417","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:17:42Z","timestamp":1761657462000},"page":"684-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of Telitacicept in Childhood\u2010Onset Systemic Lupus Erythematosus: A Prospective Multicenter Cohort Study With Inverse Probability of Treatment Weighting\u2013Adjusted Comparison to a Historical Control Group Treated With Belimumab"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-3064","authenticated-orcid":false,"given":"Chong","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First People's Hospital of Yunnan Province  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology &amp; Rheumatology The Affiliated Children's Hospital of Kunming Medical University, Kunming Children's Hospital  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunization Guiyang Maternal and Child Health Care Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Pediatric Internal Medicine Chongqing University Three Gorges Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Pediatric Immunology and Rheumatology Department Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the Second Hospital of Hebei Medical University  Shijiazhuang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunization Guiyang Maternal and Child Health Care Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Immunology and Rheumatology Department Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanhua","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the Second Hospital of Hebei Medical University  Shijiazhuang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology &amp; 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Evidence\u2010based guidelines for diagnosis and treatment of common renal diseases in children (for trial) (VI): guidelines for the diagnosis and treatment of lupus nephritis. 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