{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:06:00Z","timestamp":1790280360945,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201018\u20101\u20100717"],"award-info":[{"award-number":["W81XWH\u201018\u20101\u20100717"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anticitrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross\u2010reactive binding to many antigens containing short motifs, or private with little cross\u2010reactivity. Also, ACPA reactivity patterns differ among patients with RA, including for motif\u2010containing epitopes in important self\u2010antigens like collagen and IgG (bound by RA\u2010associated rheumatoid factors [RFs]), with limited understanding of the underlying mechanism. The objective of this study was to determine if HLA alleles associate with ACPA reactivity patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For 100 ACPA+RF+ participants with RA, serum IgG binding was quantified by enzyme\u2010linked immunosorbent assay to 10 citrulline\u2010containing peptides derived from Type II collagen and IgG1 (nine with motifs), and HLA loci were genotyped. Also, antibody and serum multireactivity were evaluated. HLA alleles present differentially in RA participants with high versus low IgG binding to specific peptides, as well as with multireactivity versus limited reactivity were identified by Fisher's exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum IgG multireactivity for citrulline\u2010glycine motif\u2010containing collagen peptides was high, at least partially due to promiscuous antibodies. HLA\u2010DQA1*01:02 was present in more participants with anticitrullinated collagen antibodies and multireactive sera. In contrast, serum multireactivity was low for IgG1\u2010derived peptides due at least in part to more private antibodies. Shared epitope\u2013containing HLA\u2010DRB1*04:01 was present more frequently in participants with RA\u2010associated RFs irrespective of the citrulline\u2010serine motif and less frequently in participants with anticitrullinated collagen antibodies. Several HLA alleles associated with specific antibody reactivities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different HLA alleles may contribute to the different reactivity patterns of promiscuous anticitrullinated collagen antibodies and more private RA\u2010associated RFs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43424","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:32:50Z","timestamp":1761892370000},"page":"603-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>Distinct HLA<\/scp>\n                    Associations for Antibody Multireactivity With Citrulline\u2010Containing Type\n                    <scp>II<\/scp>\n                    Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline\u2010Containing\n                    <scp>IgG<\/scp>\n                    Epitopes in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"S. 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