{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:15:54Z","timestamp":1784286954223,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Juvenile idiopathic arthritis (JIA) is associated with impaired overall health\u2010related quality of life (HRQoL). We evaluated the impact of tofacitinib on patient\u2010reported outcomes (PROs) in patients with JIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a post hoc analysis of a phase 3, randomized, double\u2010blind, placebo\u2010controlled withdrawal trial (NCT02592434) in patients with JIA. In the open\u2010label phase (part 1; weeks 0\u201318), patients received body weight\u2013based doses of tofacitinib. During the double\u2010blind phase (part 2; weeks 18\u201344), responders (per JIA\u2010American College of Rheumatology 30 response criteria) were randomized 1:1 to continue tofacitinib or switch to placebo for up to 26 weeks. Assessed PROs included the validated parent and\/or legal guardian versions of the Childhood Health Assessment Questionnaire for evaluation of disability, arthritis pain, overall well\u2010being, and the Child Health Questionnaire (CHQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 225 patients were enrolled and received open\u2010label tofacitinib in part 1, and 173 patients were randomized in part 2. During part 1, least\u2010squares (LS) mean (SE) disability, arthritis pain, and overall well\u2010being scores numerically improved from mean 1.04 (SE 0.05), mean 5.53 (SE 0.20), and mean 5.07 (SE 0.20) at baseline to mean 0.57 (SE 0.05), mean 2.46 (SE 0.18), and mean 2.47 (SE 0.18) at week 18, respectively. LS mean (SE) CHQ physical summary and psychological summary scores numerically improved from mean 29.51 (SE 1.15) and mean 47.24 (SE 0.85) at baseline to mean 42.70 (SE 0.98) and mean 51.53 (SE 0.80) at week 18, respectively. Improvements were generally maintained to week 44 in part 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tofacitinib improved a range of PROs in patients with JIA, suggesting potential HRQoL benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43428","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:49:21Z","timestamp":1761896961000},"page":"752-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tofacitinib for the Treatment of Juvenile Idiopathic Arthritis: Patient\u2010Reported Outcomes in a Phase 3, Randomized, Double\u2010Blind, Placebo\u2010Controlled Withdrawal Trial"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Alexeeva","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Children's Health Federal State Autonomous Institution of the Russian Federation Ministry of Health and I. M. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow  Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Principe  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Dell Children's Medical Center of Central Texas  Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Chaitow","sequence":"additional","affiliation":[{"name":"The Sydney Children's Hospital Network  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1384","authenticated-orcid":false,"given":"Peter","family":"Chiraseveenuprapund","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy V.","family":"Ting","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muferet","family":"Erguven","sequence":"additional","affiliation":[{"name":"Department of Children Health and Diseases Istanbul Medeniyet University Medical Faculty  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Cohen Children's Medical Center, New Hyde Park  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Knupp","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-7868","authenticated-orcid":false,"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Hacettepe University Medical Faculty  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Saad Magalhaes","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Universidade Estadual Paulista  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada Calvo","family":"Penad\u00e9s","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Politecnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gruben","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Groton Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Germino","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly B.","family":"Posner","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Stockert","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Collegeville Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[{"name":"University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-0130","authenticated-orcid":false,"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolino","family":"Ruperto","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano\u2010Bicocca  Milan Italy"},{"name":"Fondazione IRCCS San Gerardo dei Tintori, Reumatologia Pediatrica\/Paediatric Rheumatology International Trials Organisation  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150092"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel218"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22473"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075895"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20283"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39234"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24384"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100930"},{"issue":"5","key":"e_1_2_8_10_1","first-page":"945","article-title":"Long\u2010term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis. 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