{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:35Z","timestamp":1788309695030,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5M\u20102020\u201023682534"],"award-info":[{"award-number":["5M\u20102020\u201023682534"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Juvenile dermatomyositis (JDM) is a rare autoimmune condition. The treat\u2010to\u2010target strategy has garnered interest in pediatric rheumatology. It is based on defining clear therapeutic targets, with frequent disease activity monitoring, and adjustment of the treatments if targets are not met within a defined time frame. Recently, an international task force of experts launched an initiative aimed at the development of recommendations for the adoption of treat\u2010to\u2010target strategy in JDM. This study was done to support those recommendations. We aimed to determine the time\u2010to\u2010treatment response in patients with JDM, to better inform the development of a treat\u2010to\u2010target strategy in JDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective review of patients with a physician\u2010confirmed diagnosis of JDM, observed at two tertiary care centers\u2014the Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini (Gaslini), and The Hospital for Sick Children (SickKids). Demographic and clinical data were obtained on all patients with JDM during the first two years following diagnosis. Kaplan\u2010Meier survival curves were used to determine time to outcome definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 187 patients were identified across two sites; the mean age of diagnosis was 8 years. On average, patients with JDM achieved normalization of muscle enzymes and muscle remission three months and six months after treatment initiation, respectively. Skin remission occurred within 12 months after starting treatment. Time to reach inactive disease varied between the sites, with median time being 10.3 months (Gaslini) and 8.8 months (SickKids).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides real\u2010world data for potential timelines to target with a treat\u2010to\u2010target strategy for JDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43431","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:02:18Z","timestamp":1762772538000},"page":"928-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Toward a Treat\u2010to\u2010Target Strategy in Juvenile Dermatomyositis: What Are the Suitable Targets and Optimal Timing of Their Achievement?"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1543-0641","authenticated-orcid":false,"given":"Jayne M.","family":"MacMahon","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto Ontario Canada"},{"name":"Child Health Evaluative Sciences SickKids Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9658-0385","authenticated-orcid":false,"given":"Angelo","family":"Ravelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno\u2010Infantili Universit\u00e0 degli Studi di Genova  Genoa Italy"},{"name":"Direzione Scientifica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-3442","authenticated-orcid":false,"given":"Ana Isabel","family":"Rebollo\u2010Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Unita Operativa Complessa (UOC) Reumatologia e Malattie Autoinfiammatorie, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini  Genoa Italy"},{"name":"Department of Rheumatology Gregorio Mara\u00f1\u00f3n University Hospital, Gregorio Mara\u00f1\u00f3n Health Research Institute, Autonomous University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Natoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno\u2010Infantili Universit\u00e0 degli Studi di Genova  Genoa Italy"},{"name":"Unita Operativa Complessa (UOC) Reumatologia e Malattie Autoinfiammatorie, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Campone","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno\u2010Infantili Universit\u00e0 degli Studi di Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bovis","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 degli Studi di Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-0463","authenticated-orcid":false,"given":"Tomo","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto Ontario Canada"},{"name":"Department of Pediatrics Yokohama City University Graduate School of Medicine  Yokohama City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Ingrid","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Pediatrics The Hospital for Sick Children and University of Toronto  Toronto Ontario Canada"},{"name":"Child Health Evaluative Sciences SickKids Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-7614","authenticated-orcid":false,"given":"Alessandro","family":"Consolaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno\u2010Infantili Universit\u00e0 degli Studi di Genova  Genoa Italy"},{"name":"Unita Operativa Complessa (UOC) Reumatologia e Malattie Autoinfiammatorie, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini  Genoa 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