{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:06:55Z","timestamp":1779012415444,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic sclerosis (SSc) is an autoimmune disease characterized by autoantibody production, fibrosis, and vasculopathy. The coexistence of antineutrophil cytoplasmic autoantibody (ANCA)\u2013associated vasculitides (AAV) in SSc is rare and poorly characterized, with limited data on the impact of treatments, particularly high\u2010dose glucocorticoids (GCs), on both conditions. This study aimed to describe the clinical phenotype, management, and outcomes of patients with overlapping SSc and AAV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective study in 18 French centers, including patients who met the 2013 American College of Rheumatology (ACR)\/EULAR criteria for SSc and the 2022 ACR\/EULAR criteria for AAV. Clinical, biologic, and radiologic data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 30 patients (median age 51.5 years, 83% female). SSc preceded AAV in all cases; 27% had diffuse cutaneous SSc, whereas 73% had limited cutaneous SSc. Anti\u2010Scl70 antibodies were detected in 50%, and interstitial lung disease (ILD) was present in 80%, predominantly with a fibrosing nonspecific interstitial pneumonia pattern (54%). AAV was microscopic polyangiitis in 90%, with myeloperoxidase (MPO)\u2013ANCA positivity in 93%. Renal involvement was common (76%), with a median serum creatinine level of 170 \u03bcmol\/L (interquartile range [IQR] 120\u2013361 \u03bcmol\/L) and proteinuria (urine protein to creatinine ratio of 2 g\/g creatinine [IQR 0.9\u20132.3 g\/g creatinine]). All patients received GCs in combination with cyclophosphamide (50%) or rituximab (47%). No cases of scleroderma renal crisis were observed. SSc manifestations, including ILD and skin involvement, remained stable during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AAV, predominantly microscopic polyangiitis with MPO\u2010ANCA, can occur in SSc, particularly in patients with fibrosing ILD and anti\u2010Scl70. Standard vasculitis treatments appear to be effective and do not worsen outcomes in SSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70032","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T09:42:01Z","timestamp":1766742121000},"page":"1145-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitides in Systemic Sclerosis: A Unique Clinical Overlap With Significant Implications for Treatment and Outcomes"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4124-2391","authenticated-orcid":false,"given":"Deborah","family":"Eshagh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Qu\u00e9m\u00e9neur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier  Valenciennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Karras","sequence":"additional","affiliation":[{"name":"Department of Nephrology Georges Pompidou Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane","family":"Queyrel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-2132","authenticated-orcid":false,"given":"Jean\u2010Francois","family":"Augusto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Centre Hospitalier Universitaire  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Agard","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire Nantes, Service de m\u00e9decine interne  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Henri Mondor University Hospital, Universit\u00e9 Paris Cr\u00e9teil (AP\u2010HP), Institute Mondor of Research Biomedical  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Cez","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tenon Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Couderc","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Centre Hospitalier Universitaire, INSERM, IMosT, UMR 1240, Universit\u00e9 d'Auvergne  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duffau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile Audrey","family":"Durel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Edouard Herriot  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-0927","authenticated-orcid":false,"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplantation and National Referral Centre for Rare Kidney Diseases University Hospital of Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-1577","authenticated-orcid":false,"given":"No\u00e9mie","family":"Jourde\u2010Chiche","sequence":"additional","affiliation":[{"name":"Department of Nephrology Centre Hospitalier Universitaire  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Lavergne","sequence":"additional","affiliation":[{"name":"Department of Nephrology Centre Hospitalier Universitaire  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre de r\u00e9f\u00e9rence des Maladies Auto\u2010Immunes et Auto\u2010inflammatoires Syst\u00e9miques rares de l'Adulte du Nord, Nord\u2010Ouest, M\u00e9diterran\u00e9e et Guadeloupe, site d'Angers Centre Hospitalier Universitaire  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Limal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafik","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Department of Nephrology Centre Hospitalier  Boulogne sur Mer France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Servettaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire  Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Philipponnet","sequence":"additional","affiliation":[{"name":"Department of Nephrology Centre Hospitalier Universitaire  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrine","family":"Smets","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theophile","family":"Hubsch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital d'instruction des Arm\u00e9es Saint Anne  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-7860","authenticated-orcid":false,"given":"Benjamin","family":"Chaigne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-2454","authenticated-orcid":false,"given":"Alexis","family":"R\u00e9gent","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-9203","authenticated-orcid":false,"given":"Xavier","family":"Pu\u00e9chal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-7336","authenticated-orcid":false,"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the French Vasculitis Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00873.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<421:AID-ANR5>3.0.CO;2-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40205"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404231"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212878"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.01.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2014-000058"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"issue":"2","key":"e_1_2_6_11_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(94)90329-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm052"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-11-199706010-00003"},{"issue":"5","key":"e_1_2_6_16_1","first-page":"918","article-title":"Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis","volume":"29","author":"Ruffatti A","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1839-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/385938"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000916"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.05.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.03.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31827781fd"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac188"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106012"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102338"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.11.001"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803537"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023386"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:23:03Z","timestamp":1779009783000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/art.70032"],"URL":"https:\/\/doi.org\/10.1002\/art.70032","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}