{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:36:07Z","timestamp":1788456967591,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2024431"],"award-info":[{"award-number":["A2024431"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Dual\u2010target CAR\u2013T cell therapy targeting BCMA and CD19 is an emerging and promising treatment for systemic lupus erythematosus (SLE). However, its effects on fertility and neonatal safety are largely unknown. This report describes the outcomes of two successful pregnancies and deliveries in a patient with SLE treated with BCMA\/CD19 CAR\u2013T cell therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 24\u2010year\u2010old woman with class IV lupus nephritis received BCMA\/CD19 CAR\u2013T cell therapy. The patient achieved sustained molecular remission of SLE and became pregnant spontaneously at 6\u2010months and 21\u2010months postinfusion. We monitored for CAR\u2013T cell presence in maternal and neonatal samples and assessed the health of the infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lupus activity remained minimal without flares throughout both pregnancies. The patient had two term vaginal deliveries of healthy female infants. Serial digital polymerase chain reaction analysis of the patient's blood, breast milk, and placenta, as well as the infants\u2019 blood at birth and during follow\u2010up, were all uniformly negative for CAR\u2013T cell DNA. Both infants showed normal growth, neurodevelopment, and immune function at follow\u2010up, with no evidence of CAR\u2013T cell transmission. The patient's self\u2010reported quality of life also improved significantly after the therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that BCMA\/CD19 CAR\u2013T cell therapy may induce sustained remission (over 30 months) in SLE, preserve fertility, and result in healthy pregnancies and neonates. This finding highlights the need for evidence\u2010based guidelines for patients considering pregnancy after CAR\u2013T cell therapy.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70070-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70070","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T10:30:31Z","timestamp":1770805831000},"page":"1687-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful Spontaneous Pregnancies and Healthy Neonates After Dual\u2010Target\n                    <scp>CAR<\/scp>\n                    \u2013T Cell Therapy in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"78","author":[{"given":"Qinglian","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatoid Immunology Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatoid Immunology Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institution of Advanced Diagnostic and Clinical Medicine Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Rheumatoid Immunology Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-6631","authenticated-orcid":false,"given":"Ming","family":"Hong","sequence":"additional","affiliation":[{"name":"Institution of Advanced Diagnostic and Clinical Medicine Zhongshan People's Hospital  Zhongshan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2235"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211641"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-015-0004-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03718-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308917"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225785"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065688"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3160"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-011092"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.06.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key049"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00296-5"},{"issue":"2","key":"e_1_2_7_14_1","first-page":"146","article-title":"Neonatal outcomes following 2 cases of maternal CAR\u2010T therapy for high\u2010grade B\u2010cell lymphoma","volume":"122","author":"O'Reilly D","year":"2025","journal-title":"Neonatology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.04.005"}],"container-title":["Arthritis &amp; 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