{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:48:34Z","timestamp":1785739714286,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n Objective<\/jats:title>\n Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis relapse and GC\u2010dependent asthma and\/or ENT symptoms.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This multicenter European retrospective cohort study included patients with EGPA fulfilling the 2022 American College of Rheumatology\/EULAR criteria. Using Fine\u2010Gray and logistic regression, we developed two multivariable prediction models, one for vasculitis relapse and another for GC\u2010dependent asthma and\/or ENT symptoms at 2\u00a0Internal validation was performed using bootstrapping.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 809 patients were observed for a median of 72 months (interquartile range 37\u2013115). Vasculitis relapse occurred in 228 patients with a 12\u2010year cumulative incidence of 41.2% (95% confidence interval 36.3\u201346.8). GC\u2010dependent asthma and\/or ENT symptoms were observed in 66.4% at two years. Predictors of vasculitis relapse included age (nonlinear), GC\u2010dependent asthma before EGPA diagnosis (hazard ratio [HR] 1.57), arthralgia (HR 1.27), myocarditis (HR 1.74), peripheral neuropathy (HR 1.39), myeloperoxidase\u2013antineutrophil cytoplasmic antibody (HR 1.56), and baseline eosinophil count (nonlinear). Predictors of GC\u2010dependent asthma and\/or ENT symptoms included older age (odds ratio [OR] 0.98 per year), GC\u2010dependent asthma at diagnosis (OR 1.50), chronic sinusitis (OR 1.78), and baseline eosinophil count (OR 0.70 per 10\n 9<\/jats:sup>\n \/L).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Using a large cohort with EGPA, we developed predictive models for vasculitis relapse and GC\u2010dependent asthma and\/or ENT symptoms. These tools may help guide treatment decisions. Prospective external validation in the current therapeutic era is warranted.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.70072","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:42:16Z","timestamp":1770615736000},"page":"1710-1717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort"],"prefix":"10.1002","volume":"78","author":[{"given":"Matthias","family":"Papo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cochin Hospital, National Referral Center for Rare Systemic Autoimmune Diseases Paris 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