{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:48:39Z","timestamp":1785739719706,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitis (AAV\u2010ILD) or as an isolated entity with positive ANCA (ANCA\u2010ILD). However, data on the epidemiology and outcomes of these conditions remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A European multicenter retrospective study encompassed patients with AAV\u2010ILD or ANCA\u2010ILD. Baseline and subsequent chest computed tomography studies were centrally reviewed. Primary outcomes included forced vital capacity % (FVC%) decline, respiratory failure, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 162 patients (myeloperoxidase [MPO]\u2013ANCA 85%), 123 (76%) had AAV\u2010ILD and 39 (24%) ANCA\u2010ILD. At baseline, usual interstitial pneumonia (UIP) was the most frequent radiologic pattern (57%), whereas half had a radiologic fibrosis grade &gt;10%. Kidney involvement was present in 73%, most commonly Berden focal class. UIP and nonspecific interstitial pneumonia (NSIP) patterns showed greater annual FVC% decline than other patterns (UIP \u22121.99%, NSIP \u22123.76% [\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.35], others +0.36%). An adjusted mixed\u2010effects model indicated that rituximab was associated with mean FVC% improvement at 12 months (+6.02%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.07). Radiologic progression occurred in ~50%, mainly in younger patients with a higher fibrosis severity grade. Respiratory failure (19%) was associated with fibrosis severity (grade 4 hazard ratio [HR] 4.7,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.029) and baseline FVC% (HR 0.95,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002). Over a median 4.2\u2010year follow\u2010up, 48% died. Age (HR 1.08,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04) and baseline FVC% (HR 0.97,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.05) were independent predictors of mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At baseline, higher fibrosis severity, UIP, and lower FVC% were associated with worse outcomes. Immunosuppressives, such as rituximab, may help preserve lung function. The need for early identification and individualized treatment in ILD associated with AAV or ANCA is underscored.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70078-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70078","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:41:27Z","timestamp":1770615687000},"page":"1718-1730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis: A European Multicenter Study"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-3246","authenticated-orcid":false,"given":"Aglaia","family":"Chalkia","sequence":"first","affiliation":[{"name":"Department of Medicine University of Cambridge  United Kingdom"},{"name":"Nephrology Department General Hospital of Athens Hippokration  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marusa","family":"Kotnik","sequence":"additional","affiliation":[{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-3137","authenticated-orcid":false,"given":"Timothy J.","family":"Sadler","sequence":"additional","affiliation":[{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust  Cambridge 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