{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:51:19Z","timestamp":1788544279759,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK129762"],"award-info":[{"award-number":["K23DK129762"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF148"],"award-info":[{"award-number":["DNRF148"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n Objective<\/jats:title>\n Spondyloarthritides (SpA) and inflammatory bowel disease (IBD) are immune\u2010mediated diseases with overlap in clinical and immunologic features. However, temporal correlation of SpA and IBD in individual patients and risk factors are not well characterized.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a nationwide population\u2010based study between January 1, 1998, and July 31, 2022, to determine SpA prevalence preceding IBD diagnosis and its incidence following IBD diagnosis. Using cross\u2010linked register data, we identified individuals with IBD diagnosis and matched them to individuals without IBD. Using logistic regression, we determined the odds of SpA preceding IBD diagnosis, and using Cox regression, we determined the hazard of new\u2010onset SpA following IBD diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 102,648 individuals included in the study, 17,108 (16.7%) individuals were diagnosed with IBD. The adjusted odds ratios of SpA in the eight\u2010year period preceding IBD, Crohn disease (CD), and ulcerative colitis (UC) diagnosis, compared to matched individuals, were 1.95 (95% confidence interval [CI] 1.78\u20132.14), 2.84 (95% CI 2.43\u20133.32), and 1.61 (95% CI 1.43\u20131.81), respectively. The adjusted hazard ratios of SpA following IBD, CD, and UC diagnosis, compared to matched individuals, were 2.51 (95% CI 2.34\u20132.70), 3.17 (95% CI 2.81\u20133.59), and 2.24 (95% CI 2.05\u20132.45), respectively. SpA prevalence demonstrated temporal variability, with an increase during the few years around IBD diagnosis. Associations were stronger for axial SpA and among women and young adults following\u00a0IBD diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In a population\u2010based cohort, we report that SpA diagnosis is associated with IBD preceding and following its diagnosis. We demonstrate temporal variability and highlight clinical variables associated with SpA in IBD.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.70095","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:39:51Z","timestamp":1771511991000},"page":"1666-1673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population\u2010Based Cohort"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-1485","authenticated-orcid":false,"given":"Manasi","family":"Agrawal","sequence":"first","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine Aalborg University Copenhagen Denmark"},{"name":"The Dr Henry D. Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York New York"},{"name":"The Department of Environmental Medicine Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian N.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine Aalborg University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry J.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine Aalborg University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-3809","authenticated-orcid":false,"given":"Percio S.","family":"Gulko","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Frederic","family":"Colombel","sequence":"additional","affiliation":[{"name":"The Dr Henry D. Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Jess","sequence":"additional","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine Aalborg University Copenhagen Denmark"},{"name":"Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-019-0819-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-018-0124-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06100-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.20917"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20863"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.063"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214501753208573"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1010572"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1909094"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14222591"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz205"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202135"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00854-4"},{"issue":"5","key":"e_1_2_7_22_1","first-page":"631","article-title":"The prevalence and incidence of axial and peripheral spondyloarthritis in inflammatory bowel disease: a systematic review and meta\u2010analysis","volume":"11","author":"Karreman MC","year":"2017","journal-title":"J Crohns Colitis"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.201"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6971"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S378003"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:39:30Z","timestamp":1785739170000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/art.70095"],"URL":"https:\/\/doi.org\/10.1002\/art.70095","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"2025-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}