{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:19:45Z","timestamp":1792556385509,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR069655"],"award-info":[{"award-number":["P30AR069655"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR056702"],"award-info":[{"award-number":["R01AR056702"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR069000"],"award-info":[{"award-number":["R01AR069000"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["F30AG076326"],"award-info":[{"award-number":["F30AG076326"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["Grant F30AG076326"],"award-info":[{"award-number":["Grant F30AG076326"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG059775"],"award-info":[{"award-number":["R01AG059775"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with rheumatoid arthritis (RA) have lymphatic defects characterized by loss of collecting lymphatic vessel (cLV) contractions of unknown etiology. To elucidate underlying mechanisms, we generated transgenic mice with lymphatic\u2010specific inducible genetics and studied joint\u2010draining lymphatics in zymosan\u2010induced arthritis (ZIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We crossed novel\n                      <jats:italic>Efhd1<\/jats:italic>\n                      \u2010CreER\n                      <jats:sup>T2<\/jats:sup>\n                      and\n                      <jats:italic>Myoc<\/jats:italic>\n                      \u2010CreER\n                      <jats:sup>T2<\/jats:sup>\n                      mice to Ai9 tdTomato (tdT) reporter mice to assess tamoxifen\u2010induced transgene expression via single\u2010cell RNA sequencing, whole\u2010mount immunofluorescent microscopy (WMIFM), and immunohistochemistry. We applied electron and confocal microscopy of popliteal lymphatic vessels (PLVs) to examine \u03b1 smooth muscle actin positive lymphatic muscle cells, mast cell tryptase\u2013positive mast cells, and CD31\n                      <jats:sup>\u2212<\/jats:sup>\n                      \/CD34\n                      <jats:sup>+<\/jats:sup>\n                      cells. We crossed\n                      <jats:italic>Efhd1<\/jats:italic>\n                      \u2010CreER\n                      <jats:sup>T2<\/jats:sup>\n                      and\n                      <jats:italic>Myoc<\/jats:italic>\n                      \u2010CreER\n                      <jats:sup>T2<\/jats:sup>\n                      mice to diphtheria toxin\u2010alphafloxed mice to examine: (1) tamoxifen\u2010induced targeted cell deletion; (2) lymphatic function via near\u2010infrared imaging of injected indocyanine green; and (3) effects on ZIA in the knee via longitudinal ultrasound, micro\u2013computed tomography, and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multimodal microscopy discovered the presence of peri\u2010PLV spindle\u2010shaped cells with elongated cytoplasmic extensions physically integrated into mast cells. Gene expression studies confirmed these cells are consistent with telocytes, and WMIFM demonstrated peri\u2010PLV tdT\n                      <jats:sup>+<\/jats:sup>\n                      telocyte networks extending from capillaries in the ankle synovium to cLV near the knee. In vivo telocyte depletion decreased lymphatic drainage and exacerbated synovitis and focal erosions in ZIA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Telocyte networks extend from the synovium into mast cells proximal to joint\u2010draining cLVs, and telocyte loss is associated with synovial lymphatic system (SLS) defects and exacerbated joint pathology from inflammatory\u2010erosive arthritis. Thus, SLS telocytes are a novel drug target for RA, and interventions that maintain telocytes (eg, exercise) may improve lymphatic function.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70131-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70131","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:15:08Z","timestamp":1773674108000},"page":"2050-2062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Telocyte Deletion Associated With Loss of Lymphatic Drainage and Exacerbation of Inflammatory\u2010Erosive Arthritis in Mice"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-4772","authenticated-orcid":false,"given":"Yue","family":"Peng","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-3232","authenticated-orcid":false,"given":"H. Mark","family":"Kenney","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"de Mesy Bentley","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-7766","authenticated-orcid":false,"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-2628","authenticated-orcid":false,"given":"Benjamin D.","family":"Korman","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Division of Allergy, Immunology, Rheumatology, Department of Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-1219","authenticated-orcid":false,"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Division of Allergy, Immunology, Rheumatology, Department of Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center  Rochester New York"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.205"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000303100415"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272088"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"ZawiejaSD PeaGA BroyhillSE et al.Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells.eLife2025;12:RP90679. doi:https:\/\/doi.org\/10.7554\/eLife.90679.4","DOI":"10.7554\/eLife.90679.4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00137"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24764"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30421"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01234"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1446"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1275871"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02730-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4742"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01059.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.175018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1028-2_15"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-2039-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40903"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16884-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073766"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2022.101167"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.745096"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16225"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1174"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2103726"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-003-0125-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02438-6"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.01.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284752"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019910"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03368.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15749"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3452"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:50:22Z","timestamp":1790617822000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/art.70131"],"URL":"https:\/\/doi.org\/10.1002\/art.70131","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}