{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:04:33Z","timestamp":1790618673738,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT197771"],"award-info":[{"award-number":["PJT197771"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Immune checkpoint inhibitors (ICIs) for cancer can lead to immune\u2010related adverse events, including ICI\u2010associated inflammatory arthritis (ICI\u2010IA). There are no validated\n                      <jats:italic>International Classification of Diseases<\/jats:italic>\n                      (ICD) code\u2013based case definitions for ICI\u2010IA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a validation study using the Canadian Research Group of Rheumatology in Immuno\u2010Oncology (CanRIO) database. Rheumatologist\u2010confirmed ICI\u2010IA was the reference standard, defined as new onset of at least one swollen joint on examination or synovitis on imaging following ICI exposure, without another cause or pre\u2010existing IA. We compared ICD\u20109 (714.x and 696.0) and ICD\u201010 (M05.x, M06.x, and M07.x) IA diagnostic codes against the reference standard. Seven core case definitions of different combinations of ICD codes from the Physician Claims Database (PCD) and the Discharge Abstract Database were tested. Results were stratified by sex. Sensitivity testing with additional criteria was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 228 patients in the final analysis: 100 with ICI\u2010IA and 128 without ICI\u2010IA. Sensitivity of the tested case definitions ranged from 1.0% to 88.0%, whereas specificity ranged from 86.7% to 100.0%. The case definition with at least one PCD IA code achieved the best balance of sensitivity (88.0%, 95% confidence interval [CI] 81.6%\u201394.4%) and specificity (86.7%, 95% CI 80.8%\u201392.6%). Case definition performances were similar between sexes. Additional criteria minimally improved specificity but sacrificed sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ICD code\u2013based case definitions of ICI\u2010IA can accurately detect ICI\u2010IA and can be used to support ICI\u2010IA surveillance and research with administrative health data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70149","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:15:47Z","timestamp":1774268147000},"page":"2160-2170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of International Classification of Diseases Code\u2013Based Case Definitions of Immune Checkpoint Inhibitor\u2013Associated Inflammatory Arthritis From Administrative Health Data"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6959-4275","authenticated-orcid":false,"given":"Manar","family":"Elsayed","sequence":"first","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-4216","authenticated-orcid":false,"given":"Zoe","family":"Hsu","sequence":"additional","affiliation":[{"name":"Provincial Research Data Services, Alberta Health Services  Edmonton Alberta Canada"},{"name":"Data and Research Services Alberta SPOR SUPPORT Unit  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-3341","authenticated-orcid":false,"given":"Finlay A.","family":"McAlister","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-1691","authenticated-orcid":false,"given":"William D.","family":"Leslie","sequence":"additional","affiliation":[{"name":"University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-3212","authenticated-orcid":false,"given":"Lisa M.","family":"Lix","sequence":"additional","affiliation":[{"name":"University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-2802","authenticated-orcid":false,"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-492X","authenticated-orcid":false,"given":"Suzanne N.","family":"Morin","sequence":"additional","affiliation":[{"name":"McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-7957","authenticated-orcid":false,"given":"Michelle M.","family":"Graham","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-9825","authenticated-orcid":false,"given":"Aurore","family":"Fifi\u2010Mah","sequence":"additional","affiliation":[{"name":"University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5870-3567","authenticated-orcid":false,"given":"Shahin","family":"Jamal","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-8541","authenticated-orcid":false,"given":"Janet","family":"Roberts","sequence":"additional","affiliation":[{"name":"Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-5398","authenticated-orcid":false,"given":"Carrie","family":"Ye","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.598100"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.04.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0160-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209595"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.10.018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211216"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000412"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102595"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-02851-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab608"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.762247"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23177"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae343"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1750743X.2024.2436838"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04665-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.70100"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.03.05.25323445"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120835"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001935"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5476"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317060"},{"key":"e_1_2_6_23_1","article-title":"Population estimates, quarterly","author":"Government of Canada","year":"2024","journal-title":"Statistics Canada."},{"key":"e_1_2_6_24_1","article-title":"Checklists","author":"STROBE","journal-title":"STROBE."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/18129.8744"},{"key":"e_1_2_6_27_1","unstructured":"National Cancer Institute.CTCAE and Adverse Event Reporting.2025. Accessed September 12 2025.https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102536"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216109"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.02.011"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04451-2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11181"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002511"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001370"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2024.01.003"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-223885"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-216"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22031"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190659"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2024.02.006"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5861"},{"key":"e_1_2_6_42_1","volume-title":"The 2019 Report on Cancer Statistics in Alberta","year":"2019"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081046"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:50:47Z","timestamp":1790617847000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/art.70149"],"URL":"https:\/\/doi.org\/10.1002\/art.70149","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}