{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:02:57Z","timestamp":1790618577781,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR081791"],"award-info":[{"award-number":["R01 AR081791"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R24 AR085006"],"award-info":[{"award-number":["R24 AR085006"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether concentrations of specific per\u2010 and polyfluoroalkyl substances (PFAS) and a mixture of PFAS relate to incident knee osteoarthritis (KOA) and knee pain progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among a case\u2010cohort sample from the OA Initiative (n\u00a0=\u00a01,878), we examined associations of serum concentrations of eight PFAS with odds of developing over the subsequent 48 months (1) symptomatic KOA and (2) a clinically meaningful change in the Western Ontario and McMaster Universities OA Index knee pain score. We used weighted logistic regression to assess single PFAS (continuous and quartiles) and quantile g\u2010computation to assess the PFAS mixture in relation to our outcomes, accounting for sociodemographics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight percent of participants were female with a mean age of 62 years and body mass index of 28.6 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Participants with higher perfluorooctanoic acid (continuous) had greater odds of incident symptomatic KOA (odds ratio [OR] per interquartile range [IQR] 1.12, 95% confidence interval [CI] 1.04\u20131.21). Participants in the highest quartiles of perfluorononanoic acid (PFNA) had greater odds of incident symptomatic KOA [OR for the third quartile 1.63, 95% CI 1.29\u20132.07; fourth quartile 1.55, 95% CI 1.19\u20132.01). Perfluorooctanoic acid may have a nonlinear relationship with the greatest chance of incident symptomatic KOA with serum concentrations between 5.19 and 6.88 ng\/mL (OR 1.55, 95% CI 1.21\u20131.97). Participants with greater perfluorooctanoic acid and PFNA (continuous) had greater odds of knee pain progression (OR per IQR: perfluorooctanoic acid 1.10, 95% CI 1.03\u20131.18; PFNA 1.06, 95% CI 1.01\u20131.11). Mixture models showed perfluorooctanoic acid and PFNA were among the PFAS with the strongest positive weights for both outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a large cohort at risk for KOA, higher perfluorooctanoic acid and PFNA serum concentrations may be associated with a greater likelihood of symptomatic KOA incidence and knee pain progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70154","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:16:37Z","timestamp":1774433797000},"page":"2082-2088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Per\u2010 and Polyfluoroalkyl Substances and Knee Osteoarthritis: Data From the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-4273","authenticated-orcid":false,"given":"Jeffrey B.","family":"Driban","sequence":"first","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School  Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa B.","family":"Rokoff","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research  Westbrook Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences UConn Health  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"McAlindon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine UMass Chan Medical School  Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-9461","authenticated-orcid":false,"given":"Charles B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Prevention, Kent Hospital  Pawtucket Rhode Island"},{"name":"Department of Family Medicine Warren Alpert Medical School Brown University  Rhode Island"},{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Prevention, Kent Hospital  Pawtucket Rhode Island"},{"name":"Department of Family Medicine Warren Alpert Medical School Brown University  Rhode Island"},{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mathes","sequence":"additional","affiliation":[{"name":"Environmental and Chemical Laboratory Services, Public Health &amp; Environmental Laboratories, New Jersey Department of Health  Ewing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Lestician","sequence":"additional","affiliation":[{"name":"Environmental and Chemical Laboratory Services, Public Health &amp; Environmental Laboratories, New Jersey Department of Health  Ewing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijin Carrie","family":"Xu","sequence":"additional","affiliation":[{"name":"Environmental and Chemical Laboratory Services, Public Health &amp; Environmental Laboratories, New Jersey Department of Health  Ewing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua Tina","family":"Fan","sequence":"additional","affiliation":[{"name":"Environmental and Chemical Laboratory Services, Public Health &amp; Environmental Laboratories, New Jersey Department of Health  Ewing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn P.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Environmental and Chemical Laboratory Services, Public Health &amp; Environmental Laboratories, New Jersey Department of Health  Ewing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-2216","authenticated-orcid":false,"given":"Ida K.","family":"Haugen","sequence":"additional","affiliation":[{"name":"Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint\u2010Antoine Hospital Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de Recherche Saint\u2010Antoine (CRSA) Inserm UMRS\u2010938, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Courties","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint\u2010Antoine Hospital Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de Recherche Saint\u2010Antoine (CRSA) Inserm UMRS\u2010938, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby F.","family":"Fleisch","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research  Westbrook Maine"},{"name":"Pediatric Endocrinology and Diabetes Maine Medical Center  Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703856114"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001983"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.120916"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205673"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr107"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.70026"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.11.063"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2019.10.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210543"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c08480"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5838"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.09.009"},{"key":"e_1_2_6_16_1","author":"Centers for Disease Control and Prevention","journal-title":"National Report on Human Exposure to Environmental Chemicals"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:50:24Z","timestamp":1790617824000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/art.70154"],"URL":"https:\/\/doi.org\/10.1002\/art.70154","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}