{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:23:12Z","timestamp":1787721792529,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["199129044"],"award-info":[{"award-number":["199129044"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["277277765"],"award-info":[{"award-number":["277277765"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identification of osteoarthritis (OA)\u2013specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory\/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA\u2010associated cellular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We undertook detailed temporal flow cytometric and messenger RNA (mRNA) expression analysis in mice after sham or destabilization of the medial meniscus (DMM) surgery. This was compared with patients with meniscal injury and OA, evaluating the role of synovial monocytes\/macrophages versus lymphocytes in catabolic metalloproteinase secretion in vitro. We determined the effect of transient or delayed systemic T cell depletion on DMM\u2010induced OA pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OA\u2010inducing\/DMM and non\u2013OA\u2010inducing\/sham surgery had an identical synovial monocyte\/macrophage number, activation, and polarization. The number and activation of synovial (not splenic or peripheral blood) CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      lymphocytes were increased from one day after DMM versus sham and showed a persistent cyclical elevation throughout OA onset and progression. There was a temporal imbalance in synovial Th17\/Treg and Th1\/Th2 lymphocytes during DMM\u2010induced OA initiation and progression. We confirmed early postinjury and late OA CD3\/CD8 T cell responses in synovial tissues from patients, identified an association between CD8 and early postinjury symptoms, and defined a significant role for CD3\n                      <jats:sup>+<\/jats:sup>\n                      T cells in synovial metalloproteinase secretion. Anti\u2010CD3 cell depletion studies in mice provided an initial approach to testing this hypothesis, offering preliminary evidence that early postinjury T cell responses may be associated with long\u2010term OA pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identify a hitherto unappreciated pathophysiologic role of acute T cell activation after joint injury in long\u2010term posttraumatic OA risk, providing a novel diagnostic and therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70157","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:50:16Z","timestamp":1775649016000},"page":"1863-1877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1714-2171","authenticated-orcid":false,"given":"Babak","family":"Moradi","sequence":"first","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Orthopedic Research Center Kiel University  Kiel Germany"},{"name":"Department of Orthopedics and Trauma Surgery University Medical Center Schleswig\u2010Holstein  Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam T.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy C.","family":"Shu","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa","family":"Zaki","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Sydney School of Veterinary Science, Faculty of Science University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadrian","family":"Platzer","sequence":"additional","affiliation":[{"name":"Raymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research University of Sydney at Royal North Shore Hospital  St Leonards New South Wales Australia"},{"name":"Orthopedic Research Center Kiel University  Kiel Germany"},{"name":"Department of Orthopedics and Trauma Surgery University Medical Center Schleswig\u2010Holstein  Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Rosshirt","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center Kiel University  Kiel Germany"},{"name":"Department of Orthopedics and Trauma Surgery University Medical Center Schleswig\u2010Holstein  Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Giangreco","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R.","family":"Scanzello","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Rush University Medical Center  Chicago Illinois"},{"name":"VA CReATE Motion Center and Translational Musculoskeletal Research Center Corporal Michael J. 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