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Lung ultrasonography (LUS) has recently emerged as a possible screening tool. We assessed the role of LUS in monitoring radiologic progression and the development of new interstitial lung abnormalities (ILAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective pilot study, patients with RA underwent high\u2010resolution computed tomography (HRCT), pulmonary function tests (PFTs), symptom assessment, and LUS at baseline and 12 to 18 months later. B\u2010lines were quantified using a 72\u2010zone protocol. Radiologic changes across longitudinal HRCTs were scored on a five\u2010point Likert scale by blinded thoracic radiologists. Six multivariable logistic regression models were built to predict HRCT progression using combinations of LUS parameters, PFTs, symptoms, and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one patients completed the follow\u2010up HRCT, and per\u2010protocol LUS was performed in 95% (77\/81). Radiologic progression was observed in 31% (25\/81). An increase in B\u2010lines was significantly associated with radiologic progression (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.018), and a linear trend was confirmed (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026). In multivariable analysis, both baseline B\u2010lines (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.029) and the change in B\u2010lines over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.012) significantly predicted progression (area under the curve [AUC] 0.78, 95% confidence interval [CI] 0.64\u20130.92). When combining LUS and change in diffusing capacity for carbon monoxide (AUC 0.82, 95% CI 0.70\u20130.94), the model fit remained similar and outperformed symptom scores (AUC 0.58, 95% CI 0.40\u20130.75,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.020) and PFTs (AUC 0.59, 95% CI 0.44\u20130.74,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LUS may be a useful, radiation\u2010free tool to monitor and predict radiologic progression of ILAs in RA. These findings support further research into integrating LUS into longitudinal RA\u2010ILD assessment, particularly as part of a multimodal approach.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70161-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70161","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:14:08Z","timestamp":1775211248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung Ultrasound for the Detection of Radiologic Progression of Interstitial Lung Abnormalities in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-8638","authenticated-orcid":false,"given":"Marie","family":"Vermant","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"},{"name":"Pulmonology Department UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-7533","authenticated-orcid":false,"given":"Valerie","family":"Van Ballaer","sequence":"additional","affiliation":[{"name":"Radiology Department UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jacob","sequence":"additional","affiliation":[{"name":"Satsuma Laboratory University College London Hawkes Institute, University College London  London United Kingdom"},{"name":"University College London Respiratory, University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Follet","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Egashira","sequence":"additional","affiliation":[{"name":"Satsuma Laboratory University College London Hawkes Institute, University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Anseele","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Cypers","sequence":"additional","affiliation":[{"name":"Rheumatology Department UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens 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