{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:15:47Z","timestamp":1777990547425,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare fluorodeoxyglucose (FDG)\u2013positron emission tomography (PET) imaging to clinical\u2010 and laboratory\u2010based assessments of disease activity in a randomized controlled trial (RCT) in giant cell arteritis (GCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with new\u2010onset or relapsing GCA were randomized to guselkumab or placebo plus tapered glucocorticoids in an international, multicenter RCT. FDG\u2010PET was performed at the baseline visit before randomization and repeated at disease flare or the week\u201052 visit (clinical remission off glucocorticoids). FDG\u2010PET scans were interpreted as active or inactive by two readers, and the PET Vascular Activity Score was calculated to quantify arterial FDG uptake. FDG\u2010PET findings were compared to clinical assessment, acute phase reactants, and glucocorticoid use at each visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline FDG\u2010PET scans were interpreted as active vasculitis in 28 (55%) of 51 patients. FDG\u2010PET activity at enrollment was not associated with clinical symptoms, acute phase reactants, or risk of flare. Younger age (70 vs 76 years;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) and female sex (89% vs 48%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) were significantly associated with increased FDG\u2010PET activity. There were no differences in prior glucocorticoid dose (median 780 mg) or duration (median 23 days) between patients with baseline active versus inactive FDG\u2010PET scans. FDG\u2010PET scans were active in 17 of 21 (81%) patients during clinical flare and in 14 of 20 (70%) patients at week 52. Subsets of patients had persistently active (n = 21) or inactive (n = 9) PET scans at all time points, independent of clinical assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vascular FDG\u2010PET activity may be discordant with clinical assessment, particularly in subsets of patients with GCA. Imaging\u2010based outcome measures should remain exploratory in future therapeutic trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70166","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:20:03Z","timestamp":1775470803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>18F<\/scp>\n                    \u2010Fluorodeoxyglucose Positron Emission Tomography Imaging Assessment Within a Randomized Controlled Trial in Giant Cell Arteritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-194X","authenticated-orcid":false,"given":"Kaitlin A.","family":"Quinn","sequence":"first","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-2738","authenticated-orcid":false,"given":"Sovira","family":"Tan","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Spring House Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases Dijon\u2010Bourgogne University Hospital, University EPE Bourgogne Europe  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-1780","authenticated-orcid":false,"given":"Daniel","family":"Blockmans","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine University Hospital of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4523-8525","authenticated-orcid":false,"given":"Jean\u2010Paul","family":"Makhzoum","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Vasculitis Clinic, Hopital Sacr\u00e9\u2010Coeur de Montr\u00e9al, University of Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Cid","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases Hospital Clinic, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-6861","authenticated-orcid":false,"given":"Joerg","family":"Henes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Hematology, Oncology, Clinical Immunology, and Rheumatology) University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-9824","authenticated-orcid":false,"given":"Verena","family":"Sch\u00f6nau","sequence":"additional","affiliation":[{"name":"Department of Medicine 3, Rheumatology and Immunology Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg and Uniklinikum Erlangen  Erlangen Germany"},{"name":"Deutsches Zentrum fur Immuntherapie Freidrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg and Uniklinikum Erlangen  Erlangen 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