{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:02:56Z","timestamp":1794013376887,"version":"4.8.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1K23AR082955"],"award-info":[{"award-number":["1K23AR082955"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1UC2AR081029"],"award-info":[{"award-number":["1UC2AR081029"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["3UC2AR081039\u201002S1"],"award-info":[{"award-number":["3UC2AR081039\u201002S1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR084274"],"award-info":[{"award-number":["R01AR084274"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32\u2010AR\u2010069515"],"award-info":[{"award-number":["T32\u2010AR\u2010069515"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity is highly prevalent in psoriatic arthritis (PsA) and is associated with worse disease outcomes. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) are increasingly being used for weight loss and diabetes, but their impact on PsA outcomes remains unclear. We aimed to characterize patients with PsA initiating GLP\u20101RAs and assess longitudinal changes in weight, PsA activity, and cardiometabolic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of patients with PsA who initiated GLP\u20101RAs. PsA disease activity data and cardiometabolic parameters from clinical visits within one year before and after GLP\u20101RA initiation, along with demographics and comorbidities, were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight patients with a median body mass index of 34.9 were included. Significant weight loss was observed posttreatment (\u22126.43 kg, 95% confidence interval [CI] \u22129.5 to \u22122.0;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001), with 60% losing \u22655% of their baseline bodyweight. C\u2010reactive protein levels (\u22121.1 mg\/L;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002), pain scores (\u22121.0;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01), and triglyceride levels (\u22120.35 mmol\/L;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02) decreased significantly. Each 1% reduction in body weight was associated with significant improvements in the Disease Activity in Psoriatic Arthritis score (\u03b2 = \u22120.49, 95% CI \u22120.94 to \u22120.03), tender joint count (\u03b2 = \u22120.18, 95% CI \u22120.32 to \u22120.05), EuroQol 5\u2010domain (\u03b2 = 0.0016, 95% CI 0.008\u20130.023), low\u2010density lipoprotein cholesterol levels (\u03b2 = \u22120.05, 95% CI \u22120.10 to \u22120.003), and systolic blood pressure (\u03b2 = \u22120.67, 95% CI \u22121.18 to \u22120.15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real\u2010world study, GLP\u20101RA therapy in PsA was associated with clinically meaningful weight loss and improvements in systemic inflammation, pain, and cardiometabolic markers. Improvements in psoriatic outcomes were proportional to the degree of weight loss. These findings warrant further investigation in prospective controlled studies to evaluate the role of GLP\u20101RAs in PsA management and comorbidities.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70170-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70170","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:51:55Z","timestamp":1775472715000},"page":"2274-2279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonist Therapy Is Associated With Improvement in Psoriatic Arthritis\u2013Related and Metabolic Outcomes: A Retrospective Analysis of Two Cohorts"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-8136","authenticated-orcid":false,"given":"Rebecca H.","family":"Haberman","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology New York University (NYU) Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology New York University (NYU) Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology New York University (NYU) Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Scher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology New York University (NYU) Grossman School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Thib","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology University of Toronto and Women's College Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-6994","authenticated-orcid":false,"given":"Jose U.","family":"Scher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology New York University (NYU) Grossman School of Medicine  New York New York"},{"name":"NYU Colton Center for Autoimmunity, NYU Langone Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-1715","authenticated-orcid":false,"given":"Lihi","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology University of Toronto and Women's College Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-019-00172-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-025-01326-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204448"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403664"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1826392"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04609.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2232-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12886"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0396-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195123"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21711"},{"issue":"9","key":"e_1_2_6_14_1","article-title":"Dietary interventions in psoriatic arthritis: a randomized controlled clinical trial [abstract]","volume":"77","author":"Eder L","year":"2025","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.05.021"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reumae.2025.501809"}],"container-title":["Arthritis &amp; 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