{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:21:30Z","timestamp":1791699690983,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["259696"],"award-info":[{"award-number":["259696"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007211","name":"Vasculitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"abstract":"\n Objective<\/jats:title>\n To assess the 2022 American College of Rheumatology (ACR)\/EULAR classification criteria for antineutrophil cytoplasmic antibody\u2013associated vasculitis (AAV) in children with chronic small\u2010to\u2010medium vessel vasculitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cohort of 574 patients, identified by physician's diagnosis (MD\u2010diagnosis) in A Registry of Childhood Vasculitis, was classified by computation of registry data as having granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or eosinophilic GPA after applying (1) ACR\/EULAR AAV criteria and (2) pediatric\u2010adapted European Medicines Agency (Ped\u2010EMA) classification algorithm (incorporating Ankara GPA criteria). Venn diagrams compared the resulting GPA and MPA cohorts with MD\u2010diagnosis. Sensitivity and specificity of criteria for GPA were evaluated against MD\u2010diagnosis. Fisher exact test evaluated differences in the frequencies of individual clinical features in GPA versus MPA.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Comparing ACR\/EULAR criteria against the Ped\u2010EMA algorithm for classifying AAV, more patients were classified as GPA or MPA (n\u00a0=\u00a0396 vs 360, respectively), fewer had GPA (n\u00a0=\u00a0261 vs 288, respectively), more had MPA (n\u00a0=\u00a0135 vs 72, respectively), and fewer GPA cases coclassified as MPA (12% vs 28%, respectively); there were more differences between GPA and MPA in Pediatric Vasculitis Activity Score\u2013defined clinical features (n\u00a0=\u00a014 vs 10, respectively). When classifying GPA by ACR\/EULAR or Ankara criteria, sensitivity (74.5% vs 72.1%, respectively) was comparable, and specificity for ACR\/EULAR criteria (93.9% vs 79.9%, respectively) was improved.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The 2022 ACR\/EULAR classification criteria for AAV perform at least as well as previous pediatric criteria and provide categorical MPA criteria where none existed previously; the criteria for GPA and MPA now specifically differentiate each other, with more differences between them in the frequencies of clinical features. Our findings support the preferential use of ACR\/EULAR over Ankara criteria for GPA in pediatrics.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.70172","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:25:31Z","timestamp":1775802331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effective Performance of the 2022 American College of Rheumatology\/\n EULAR<\/scp>\n Classification Criteria for Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis in Pediatric Patients: An\n ARChiVe<\/scp>\n Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-9210","authenticated-orcid":false,"given":"David A.","family":"Cabral","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else S.","family":"Bosman","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"McPhate","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8086-3604","authenticated-orcid":false,"given":"Simranpreet K.","family":"Mann","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6192-769X","authenticated-orcid":false,"given":"Kirandeep K.","family":"Toor","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Morishita","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology British Columbia Children's Hospital Vancouver British Columbia Canada"},{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raashid","family":"Luqmani","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Beresford","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"},{"name":"Department of Paediatric Rheumatology Alder Hey Children's NHS Foundation Trust Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9545-8776","authenticated-orcid":false,"given":"James","family":"Bistolarides","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Campillo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Montreal Children's Hospital Quebec 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