{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:04:17Z","timestamp":1780470257688,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371816"],"award-info":[{"award-number":["82371816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460411"],"award-info":[{"award-number":["82460411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602000"],"award-info":[{"award-number":["2022YFC3602000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease driven by neutrophil dysregulation and neutrophil extracellular trap (NET) formation, with unmet therapeutic needs. This study aimed to investigate the therapeutic potential of protein kinase CK2 inhibitor CX\u20104945 in SLE as well as to elucidate the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CX\u20104945 was administered to multiple murine models, including MRL\/lpr mice, imiquimod (IMQ)\u2010induced lupus model, IMQ\u2010induced psoriasis model, and cecal ligation and puncture\u2013induced sepsis model. Renal function, histopathological changes, immune complex deposition, NET formation, and inflammatory cytokine levels were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CX\u20104945 significantly ameliorated renal damage in MRL\/lpr and IMQ\u2010induced lupus models, as evidenced by reduced urinary albumin\u2010to\u2010creatinine ratio, glomerular abnormalities, immune complex\/complement C3 deposition, and neutrophil infiltration. The neutrophils from patients with SLE exhibited elevated CK2\u03b1 expression and enzyme activity. Mechanistically, CX\u20104945 suppressed interferon\u2010stimulated genes and reactive oxygen species\u2013related pathways, induced mitochondrial metabolic rewiring, inhibited JNK\/p38 MAPK phosphorylation, and modified NET protein composition to abrogate macrophage proinflammatory responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CK2\u03b1 is aberrantly up\u2010regulated in SLE neutrophils, and targeting CK2 with CX\u20104945 exerts therapeutic effects in SLE. These findings identify CK2 as a novel therapeutic target for SLE and support the repurposing of CX\u20104945 for treating neutrophil\u2010driven inflammatory and autoimmune diseases.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70206-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70206","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:25:25Z","timestamp":1778055925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Targeting Protein Kinase\n                    <scp>CK2<\/scp>\n                    Ameliorates Lupus Nephritis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1535-8222","authenticated-orcid":false,"given":"Minghua","family":"Zhan","sequence":"first","affiliation":[{"name":"Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of National Health Commission Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of 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