{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:19:45Z","timestamp":1792556385228,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR069655"],"award-info":[{"award-number":["P30AR069655"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG059775"],"award-info":[{"award-number":["R01AG059775"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR056702"],"award-info":[{"award-number":["R01AR056702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR069000"],"award-info":[{"award-number":["R01AR069000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"abstract":"\n Objective<\/jats:title>\n Telocytes are interstitial mesenchymal cells that facilitate intercellular communication and mediate tissue homeostasis and remodeling. Telocyte loss is associated with autoimmune and fibrotic diseases, including rheumatoid arthritis (RA). Thus, we aimed to characterize the genomics, functions, and fibroblast phenotypic transition potential of synovial telocytes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed single\u2010cell RNA sequencing (scRNA\u2010seq) to phenotype mesenchymal populations in mouse knees and analyzed human synovial scRNA\u2010seq data from publicly available databases. Immunohistochemistry (IHC) on normal and arthritic joints from\n Efhd1<\/jats:italic>\n \u2010CreER\n T2<\/jats:sup>\n \u00d7 Ai9 tdTtomato (tdT) reporter and tumor necrosis factor transgenic (TNF\u2010tg) mice assessed synovial telocytes versus fibroblasts. Cocultures of tdT\n +<\/jats:sup>\n telocytes and tdT fibroblasts were assessed for responses to osmotic shock via fluorescent microscopy of Fluo4 and MitoSOX Green. Invasive phenotypes were assessed in Matrigel assays. Telocyte\u2010to\u2010fibroblast plasticity in response to matrix stiffness was evaluated using bulk RNA\u2010seq.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Uniform manifold approximation and projections demonstrated that\n Efhd1, Dpp4,<\/jats:italic>\n and\n Pi16<\/jats:italic>\n are specific marker genes that distinguish telocytes from\n Comp<\/jats:italic>\n \u2010,\n Dkk3<\/jats:italic>\n \u2010, and\n Cdh11<\/jats:italic>\n \u2010expressing fibroblasts in normal murine and human synovium. IHC confirmed tdT\n +<\/jats:sup>\n synovial telocytes are CD34\n +<\/jats:sup>\n \/Comp\n \u2212<\/jats:sup>\n , primarily reside in the sublining, and are lost during TNF\u2010induced arthritis. In vitro, telocytes are more sensitive to osmotic pressure than fibroblasts, have a unique mitoflash response to this stimulus, and lose marker gene expression while acquiring myofibroblast markers in response to a stiff matrix.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Synovial telocytes are Efhd1\n +<\/jats:sup>\n \/ Dpp4\n +<\/jats:sup>\n \/Pi16\n +<\/jats:sup>\n , function as lymphatic sensors to monitor osmotic pressure, and differentiate into fibroblasts in response to matrix stiffness. Their relative absence in RA synovium is associated with decreased lymphatic function and disease progression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.70241","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:51:22Z","timestamp":1781524282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synovial Telocytes Are Characterized by\n Efhd1, Dpp4<\/i>\n , and\n Pi16<\/i>\n Expression, Show High Responsiveness to Osmotic Stress, and Exhibit Fibroblast Plasticity Potential"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-4772","authenticated-orcid":false,"given":"Yue","family":"Peng","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Pathology & Laboratory Medicine University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Kobryn","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Orthopaedics University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-7766","authenticated-orcid":false,"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Pathology & Laboratory Medicine University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-2628","authenticated-orcid":false,"given":"Benjamin D.","family":"Korman","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Medicine, Division of Allergy, Immunology, and Rheumatology University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-1219","authenticated-orcid":false,"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Medicine, Division of Allergy, Immunology, and Rheumatology University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester Medical Center Rochester New York"},{"name":"Department of Pathology & Laboratory Medicine University of Rochester Medical Center Rochester New York"},{"name":"Department of Orthopaedics University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis \u2010 common origins, divergent mechanisms","volume":"388","author":"Gravallese EM","year":"2023","journal-title":"N Engl J Med"},{"issue":"12","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini S","year":"2022","journal-title":"Immunity"},{"issue":"5","key":"e_1_2_7_4_1","first-page":"1607","article-title":"Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted 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