{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:02:58Z","timestamp":1784595778530,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente"],"award-info":[{"award-number":["Ricerca Corrente"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Antiphospholipid antibodies (aPL) may directly affect placentation and trigger local complement\u2010mediated inflammation\/thrombosis. Obstetric complications in the antiphospholipid syndrome (APS) are still frequent despite therapy\/close monitoring, and the identification of new risk biomarkers is an unmet need. We aimed to prospectively investigate the prognostic value of classification\/nonclassification laboratory APS criteria and markers of complement activation for pregnancy complications, in particular preterm delivery (PTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We observed 60 women prospectively during pregnancy and postpartum: 33 aPL\u2010positive (20 APS and 13 aPL\u2010carriers) and 27 aPL\u2010negative (5 systemic lupus erythematosus, 11 rheumatoid arthritis and 11 undifferentiated connective tissue diseases). aPL criteria tests, anti\u2010phosphatidylserine\/prothrombin (anti\u2010PS\/PT) IgG\/IgM and anti\u2010\u03b22glycoprotein I\u2010Domain I IgG, complement products (C3, C4, C3a, C5a, sC5b\u20109, MBL) and complement pathway activity (classical pathway [CP], alternative pathway [AP], and lectin pathway [LP]) were measured in 231 available specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTD was experienced in 21% of aPL\u2010positive and 15% of aPL\u2010negative women. Anti\u2010PS\/PT IgG\/IgM titers were significantly higher in PTD versus non\u2010PTD women (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) at almost all time points. At variance with CP and AP, LP activity in aPL\u2010positive PTD was lower than in non\u2010PTD, reaching a statistically significant difference compared with aPL\u2010negative PTD patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Moreover, LP activity significantly correlated with anti\u2010PS\/PT IgG\/IgM titers, both measured in the first trimester (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and all of them significantly correlated with the week of gestation at delivery (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The reduced LP activity and the higher anti\u2010PS\/PT IgG\/IgM titers in PTD aPL\u2010positive women during the first trimester suggest their use as early prognostic tools for PTD in aPL\u2010positive pregnant women.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70273-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70273","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:40:51Z","timestamp":1783942851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Anti\u2010Phosphatidylserine\/Prothrombin Antibodies and the Lectin Complement Pathway in Anti\u2010Phospholipid Antibody\u2010Associated Preterm Delivery"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-7535","authenticated-orcid":false,"given":"Arianna","family":"Da Via","sequence":"first","affiliation":[{"name":"Laboratory of ImmunoRheumatologic Researches IRCCS Istituto Auxologico Italiano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria O.","family":"Borghi","sequence":"additional","affiliation":[{"name":"Laboratory of ImmunoRheumatologic Researches IRCCS Istituto Auxologico Italiano  Milan Italy"},{"name":"Dipartimento di Scienze Cliniche e di Comunit\u00e0, Dipartimento di Eccellenza 2023 to 2027 University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trespidi","sequence":"additional","affiliation":[{"name":"S.C. Ostetricia, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia M.","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"S.C. 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Ostetricia, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e di Comunit\u00e0, Dipartimento di Eccellenza 2023 to 2027 University of Milan  Milan Italy"},{"name":"ASST Pini CTO, Lupus Clinic, Division of Clinical Rheumatology  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica G.","family":"Gazzola","sequence":"additional","affiliation":[{"name":"S.C. 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