{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:02Z","timestamp":1787833082049,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the prevalence and longitudinal evolution of anti\u2013carbamylated fibrinogen antibodies (ACa\u2010Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA) and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti\u2013cyclic citrullinated peptide (anti\u2010CCP) antibodies and rheumatoid factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ACa\u2010Fib IgG and IgA were quantified by in\u2010house enzyme\u2010linked immunosorbent assay at baseline and 6 and 24 months in 619 patients with available 2010 American College of Rheumatology\/EULAR classification criteria, including 575 patients with RA, from the French ESPOIR cohort. Clinical, biologic, and radiographic data were collected. Multivariable models and appropriate statistical analyses were used to assess associations between ACa\u2010Fib levels and disease activity, therapeutic response, smoking exposure, C\u2010reactive protein concentrations, and structural progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, ACa\u2010Fib IgG and IgA were detected in 16.6% and 6.3% of patients with anti\u2010CCP\u2013negative RA, respectively. Baseline ACa\u2010Fib levels were not associated with therapeutic response or remission. Over 24 months, ACa\u2010Fib IgG levels decreased, whereas IgA levels remained stable. Higher ACa\u2010Fib IgA levels were associated with longer smoking duration (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003) and cumulative smoking exposure (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.016). Patients in the highest quartile of ACa\u2010Fib IgG (\u226520.29 arbitrary units [AU]) had an increased risk of rapid radiographic progression (global\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004). Despite its markedly lower prevalence, ACa\u2010Fib IgA (\u22653.07 AU) was also associated with structural progression (odds ratio 1.9, 95% confidence interval 1.1\u20133.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The distinct longitudinal behavior and prognostic associations of ACa\u2010Fib IgG and IgA highlight a previously underappreciated component of the anti\u2013carbamylated protein response and support their utility as complementary biomarkers for improved risk stratification in early RA.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70281-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70281","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:29:46Z","timestamp":1785137386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2013Carbamylated Fibrinogen Autoantibodies of\n                    <scp>IgG<\/scp>\n                    and\n                    <scp>IgA<\/scp>\n                    Isotypes Contribute to a Better Prognostic Stratification in Very Early Rheumatoid Arthritis: Data From the French National\n                    <scp>ESPOIR<\/scp>\n                    Cohort"],"prefix":"10.1002","author":[{"given":"Pauline","family":"Brevet","sequence":"first","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology and CIC\u2010CRB 1404  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5193-7803","authenticated-orcid":false,"given":"Olivia","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"CHU Rouen, Department of Biostatistics and Clinical Research  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9na","family":"Le Goar\u00e9guer","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology and CIC\u2010CRB 1404  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lisa","family":"Halbourg","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Golinski","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Dermatology  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Candon","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Immunology and Biotherapies  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-307X","authenticated-orcid":false,"given":"Olivier","family":"Boyer","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Immunology and Biotherapies  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lequerr\u00e9","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology and CIC\u2010CRB 1404  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Schaeverbeke","sequence":"additional","affiliation":[{"name":"Rheumatology Department, CHU Bordeaux, Groupe Hospitalier Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-825X","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Devauchelle\u2010Pensec","sequence":"additional","affiliation":[{"name":"Rheumatology Department Brest University Hospital, CIC 1412, Inserm  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Vittecoq","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology and CIC\u2010CRB 1404  F\u201076000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-7828","authenticated-orcid":false,"given":"Manuel","family":"Fr\u00e9ret","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology and CIC\u2010CRB 1404  F\u201076000 Rouen 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