{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:06:35Z","timestamp":1788912395771,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy (tumor necrosis factor inhibitors [TNFi], interleukin\u201017 inhibitors [IL\u201017i], IL\u201012\/23i, IL\u201023i, JAK inhibitors [JAKi]) from January 2014 to September 2022. Patients with prior cancer, HIV infection, or organ transplantation were excluded. Follow\u2010up began after a three\u2010month delay and continued until December 2024. Exposure was assessed annually and classified as \u22646 or &gt;6 months per year. Incident cancer was the primary outcome. Weighted Cox marginal structural models with inverse probability of treatment and censoring weights were used. A post hoc sensitivity analysis evaluated cumulative exposure trajectories over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 56,591 patients (53.9% women; mean\u2009\u00b1\u2009SD age 44\u2009\u00b1\u200913 years; median follow\u2010up 5.0 years). During follow\u2010up, 1,224 cancers occurred (1,029 solid, 116 hematological, 79 unclassified). Exposure &gt;6 months versus \u22646 months was associated with a lower risk of overall cancer (weighted hazard ratio [wHR] 0.86, 95% confidence interval [CI] 0.75\u20130.99). In subgroup analyses, this association was observed for hematological malignancies (wHR 0.65, 95% CI 0.42\u20130.99) but not for solid cancers (wHR 0.92, 95% CI 0.79\u20131.07). Cumulative exposure history was not associated with cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide study, prolonged exposure to targeted therapies was not associated with an increased cancer risk. Exposure &gt;6 months per year was associated with a lower cancer risk, mainly for hematological malignancies, whereas cumulative exposure over multiple years was not associated with cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70297","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:19:48Z","timestamp":1786961988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database"],"prefix":"10.1002","author":[{"given":"Karine","family":"Tankovic","sequence":"first","affiliation":[{"name":"EPILOGY, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955 Universit\u00e9 Paris\u2010Est Cr\u00e9teil  Cr\u00e9teil France"},{"name":"Service de Rhumatologie, H\u00f4pital Henri Mondor, AP\u2010HP 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