{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:04:11Z","timestamp":1789365851400,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TR004374"],"award-info":[{"award-number":["TR004374"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319\/SLAMF7\u2010expressing cytotoxic T cells implicated in diffuse cutaneous SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this ancillary ASSET trial analysis, peripheral blood mononuclear cells from 67 participants were analyzed at baseline and months one, three, and six. Flow cytometry quantified CD4+CD319+ and CD8+CD319+ T cells, cytotoxic and activation markers, and stimulated intracellular interleukin\u20104 (IL\u20104), IL\u201017A, and interferon\u2010\u03b3 (IFN\u2010\u03b3). Analyses compared abatacept\u2010treated molecular endotypes with placebo and related immune changes to modified Rodnan skin score (mRSS) change. Skin single\u2010cell RNA sequencing included five healthy controls and eight patients with SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, CD319+ T cells showed greater cytokine production, activation, and granzyme and perforin expression than CD319\u2212 T cells in 60 evaluable participants (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 to\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). Abatacept reduced CD4+CD319+ and CD8+CD319+ T cell frequencies at month six; placebo did not. Effects were strongest in patients in the fibroproliferative group, in whom CD8+CD319+ T cells decreased versus placebo (n = 7 versus n = 36;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0377). In this endotype, abatacept reduced IL\u20104 in CD4+CD319+ and CD8+CD319+ T cells at month three (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0468 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0287) and IL\u201017A in CD8+CD319+ T cells at month six (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0004), whereas IFN\u2010\u03b3 was unchanged. Reduction in CD4+CD319+ T cells correlated with mRSS improvement in abatacept\u2010treated patients (r = 0.5297,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0423). Skin single\u2010cell RNA sequencing showed increased\n                      <jats:italic>SLAMF7<\/jats:italic>\n                      expression in SSc T cells (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.017), enriched within cytotoxic subsets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CD319+ T cells represent highly differentiated, activated cytotoxic effector populations in SSc. Abatacept selectively modulates these cells and suppresses associated profibrotic and proinflammatory cytokines, particularly in the fibroproliferative subtype, in which CD319+ T cell reductions correlate with clinical improvement.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70301-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70301","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:38:02Z","timestamp":1787222282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abatacept Reduces\n                    <scp>CD319<\/scp>\n                    + (\n                    <scp>SLAMF7<\/scp>\n                    ) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-1751","authenticated-orcid":false,"given":"Mikel","family":"Gurrea\u2010Rubio","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-2548","authenticated-orcid":false,"given":"Laura 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