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Leveraging the Centers for Disease Control and Prevention (CDC) National Lupus Registry network of population\u2010based SLE registries, meta\u2010analyses were performed estimating age\u2010specific incidence of SLE by sex, race, and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CDC network of SLE registries includes five state\u2010based registries, plus a sixth Indian Health Service registry. Incidence periods spanned calendar years 2002 to 2018. Registries provided age\u2010specific incidence of SLE, fulfilling the American College of Rheumatology SLE classification criteria, per 100,000 person\u2010years, stratified by sex, race, and ethnicity for the meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incidence rates among women were highest for those aged 30 to 39 years (12.7, 95% confidence interval [CI] 9.5\u201316.8), whereas rates among men were highest for those aged 60 to 69 years (2.1, 95% CI 1.3\u20133.4). Black women aged 20 to 39 years had the highest SLE incidence rates (23.6, 95% CI 20.7\u201326.8). Among women diagnosed with SLE before age 20 years, incidence was highest among Asian individuals (6.5, 95% CI 2.8\u201315.2). Among women diagnosed with SLE after age 60 years, incidence was highest among American Indian\/Alaska Native individuals (9.4, 95% CI 3.4\u201315.4). Weighted percentages show 10.0% of those with SLE were diagnosed before age 20 years, whereas 15.1% were diagnosed after age 60 years. The largest proportion of individuals with SLE (22.1%) was diagnosed between ages 30 and 39 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides comprehensive sex\u2010 and race\u2010specific estimates of age at SLE diagnosis. The substantial later\u2010in\u2010life SLE incidence among men and disease burden in pediatric and older populations should raise awareness in considering SLE in the differential diagnosis in previously underrecognized groups.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70306-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70306","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:39:54Z","timestamp":1787571594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Specific Incidence of Systemic Lupus Erythematosus in the United States: A Meta\u2010Analysis of Data From the Centers for Disease Control and Prevention Lupus Registries"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-2182","authenticated-orcid":false,"given":"Peter M.","family":"Izmirly","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine New York University Grossman School of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-8205","authenticated-orcid":false,"given":"Elizabeth D.","family":"Ferucci","sequence":"additional","affiliation":[{"name":"Division of Community Health Services, Department of Research Services Alaska Native Tribal Health Consortium  Anchorage"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-0010","authenticated-orcid":false,"given":"Aimee O.","family":"Hersh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Pediatrics Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-0787","authenticated-orcid":false,"given":"S. Sam","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-7291","authenticated-orcid":false,"given":"Cristina","family":"Drenkard","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-5719","authenticated-orcid":false,"given":"Ali","family":"Duarte\u2010Garcia","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Mayo Clinic  Rochester 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