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The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue\u2010derived proteins. Thus, we applied a dual antibody\u2010based proximity extension assay to profile &gt;1,000 proteins in subtypes of patients with IIM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma samples from 201 patients diagnosed with IIM at Karolinska University Hospital were analyzed using Olink Proximity Extension Assay technology. Clinical manifestations, disease activity measurements, and laboratory test results were collected. First, we evaluated differential protein abundance across IIM subtypes. Then we calculated tissue scores for each disease subtype using tissue gene expression databases. Finally, interferon (IFN) pathway scores were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma from patients with dermatomyositis was enriched for IFN signaling and skin\u2010associated proteins, antisynthetase syndrome (ASyS) for lung\u2010associated proteins, immune\u2010mediated necrotizing myopathy (IMNM) for muscle\u2010associated proteins, and inclusion body myositis for T cell\u2013response proteins. Patients with IMNM showed the highest tissue score for skeletal muscles, and patients with ASyS showed the highest lung tissue scores. Skeletal muscle scores correlated strongly with muscle disease activity visual analog scale scores, creatine kinase levels, and muscle weakness score. Patients with interstitial lung disease along with anti\u2010MDA5 and those with anti\u2010Jo1 autoantibodies showed differential enrichment of surfactant proteins and IFN pathway activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circulatory proteome is a promising tool to capture distinct tissue\u2010specific responses that correlate with disease activity and tissue injury in patients with IIM.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70311-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70311","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:58:37Z","timestamp":1787828317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-0154","authenticated-orcid":false,"given":"Yue\u2010Bei","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neurology Xiangya Hospital, Central South University  Changsha China"},{"name":"Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Center for Molecular Medicine Karolinska University Hospital  Stockholm 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