{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:17:59Z","timestamp":1788419879945,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"\n Objective<\/jats:title>\n \n Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early post\u2010injury biological processes within the synovium shape disease trajectories. We investigated whether synovial regulatory T (T\n reg<\/jats:sub>\n ) cells are engaged during the early phase following joint injury and whether experimental enrichment of this compartment is associated with altered local inflammation and PTOA\u2010related pathology.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Using surgically induced destabilization of the medial meniscus (DMM) and a non\u2010invasive anterior cruciate ligament (ACL) rupture model in mice, we characterized temporal dynamics and phenotypes of synovial T\n reg<\/jats:sub>\n cells by high\u2010parameter flow cytometry and integrative single\u2010cell transcriptomic analysis. T\n reg<\/jats:sub>\n cells were preferentially expanded using systemic low\u2010dose IL\u20102\/anti\u2013IL\u20102 complexes or intraarticular adeno\u2010associated virus\u2013mediated IL\u20102 delivery. Synovial inflammation, cartilage degeneration, and gait function were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Synovial T\n reg<\/jats:sub>\n cells accumulated rapidly after joint injury in both models, acquired activation\u2010 and tissue\u2010adaptation\u2010associated phenotypes distinct from lymphoid T\n reg<\/jats:sub>\n populations, and were associated with local immune\u2010compositional changes. Experimental IL\u20102\u2013mediated enrichment of the synovial T\n reg<\/jats:sub>\n compartment was accompanied by reduced synovitis, attenuated cartilage pathology, and partial improvement in load\u2010bearing gait parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Early synovial T\n reg<\/jats:sub>\n engagement represents a candidate joint\u2010localized immunoregulatory feature of PTOA initiation. Experimental enrichment of this compartment was associated with attenuated PTOA\u2010related features, supporting further investigation of T\n reg<\/jats:sub>\n \u2010specific mechanisms and precisely timed, joint\u2010localized immune modulation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.70321","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:10:50Z","timestamp":1788419450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early synovial regulatory T cell engagement in posttraumatic osteoarthritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-517X","authenticated-orcid":false,"given":"Xueyou","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-7856","authenticated-orcid":false,"given":"Mingde","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruma Sai\u2010Chuen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Tim\u2010Yun","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"CUHK Medical Centre, Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Shu\u2010Hang","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Center for Neuromusculoskeletal Restorative Medicine (CNRM) The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"CUHK Medical Centre, Department of Orthopaedics & Traumatology, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:10:51Z","timestamp":1788419451000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":0,"alternative-id":["10.1002\/art.70321"],"URL":"https:\/\/doi.org\/10.1002\/art.70321","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"2026-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"art.70321"}}