{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:54:55Z","timestamp":1790952895068,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70329-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70329","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:17:15Z","timestamp":1790342235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Avacopan in Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis: Real\u2010World Safety After Postmarketing Liver Injury Signals"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2720-9934","authenticated-orcid":false,"given":"Iftach","family":"Sagy","sequence":"first","affiliation":[{"name":"Addenbrooke's Vasculitis and Lupus Department Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"},{"name":"Department of Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Addenbrooke's Vasculitis and Lupus Department Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"},{"name":"Department of Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Francis","sequence":"additional","affiliation":[{"name":"Addenbrooke's Vasculitis and Lupus Department Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"},{"name":"Department of Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel B.","family":"Jones","sequence":"additional","affiliation":[{"name":"Addenbrooke's Vasculitis and Lupus Department Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"},{"name":"Department of Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_1_3_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111179"},{"key":"e_1_2_1_3_3_1","unstructured":"US Food and Drug Administration.FDA identifies cases of serious liver injury in patients taking Tavneos (avacopan) for severe active anti\u2010neutrophil cytoplasmic autoantibody (ANCA)\u2010associated vasculitis. Published online March31 2026. Accessed June 24 2026.https:\/\/www.fda.gov\/drugs\/drug-safety-communications\/fda-identifies-cases-serious-liver-injury-patients-taking-tavneos-avacopan-severe-active-anti"},{"key":"e_1_2_1_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"},{"key":"e_1_2_1_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70001"},{"key":"e_1_2_1_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med4.70056"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:20:43Z","timestamp":1790950843000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":5,"alternative-id":["10.1002\/art.70329"],"URL":"https:\/\/doi.org\/10.1002\/art.70329","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"art.70329"}}