{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:41:22Z","timestamp":1792392082123,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of bimekizumab, a dual interleukin (IL)\u201017A and IL\u201017F inhibitor, on sacroiliac joints (SIJ) and spine inflammation\/structural damage in axSpA using magnetic resonance imaging (MRI) scans\/radiographs from the phase 3 studies BE MOBILE 1 (non\u2010radiographic axSpA [nr\u2010axSpA]) and 2 (radiographic axSpA [r\u2010axSpA]) and their open\u2010label extension (OLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BE MOBILE 1 and 2 comprised 16\u2010week double\u2010blind placebo\u2010controlled and 36\u2010week maintenance periods. From week 16, all received subcutaneous bimekizumab 160 mg every 4 weeks. At week 52, patients could enter the OLE to continue bimekizumab. MRI scans were evaluated by treatment arm at baseline and weeks 16 and 52 in BE MOBILE 1 and 2 MRI substudies using Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ and Berlin spine inflammation scores, and SPARCC SIJ structural score (SSS; erosion, backfill, fat lesions, and ankylosis). In patients with baseline and week 104 radiographs, structural damage was assessed in the SIJ (modified New York [mNY] criteria; nr\u2010axSpA) and spine (modified Stoke Ankylosing Spondylitis Spinal Score [mSASSS]; r\u2010axSpA). Observed case data are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At week 52, bimekizumab\u2010randomized patients had substantially reduced inflammation (mean change from baseline [CfB]: SPARCC SIJ, nr\u2010axSpA \u20137.6; r\u2010axSpA \u20135.1; Berlin spine, nr\u2010axSpA \u20130.5; r\u2010axSpA \u20132.5), decreased erosion scores (nr\u2010axSpA \u20131.8; r\u2010axSpA \u20131.8), increased backfill (nr\u2010axSpA 0.9; r\u2010axSpA 0.6) and fat lesion scores (nr\u2010axSpA 0.7; r\u2010axSpA 0.5), and minimal changes in ankylosis (nr\u2010axSpA 0.0; r\u2010axSpA 0.2). With bimekizumab treatment to week 104, radiographs showed mean CfB of 0.03 in mNY (nr\u2010axSpA) and mSASSS of 0.3 (r\u2010axSpA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dual inhibition of IL\u201017A and IL\u201017F with bimekizumab led to substantial reductions in MRI SIJ\/spine inflammation, gradual decreases in SIJ erosion, and minimal radiographic progression in the SIJ\/spine in patients with axSpA.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70336-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70336","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:03:26Z","timestamp":1789452206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Dual Interleukin\u2010\n                    <scp>17A<\/scp>\n                    and Interleukin\u2010\n                    <scp>17F<\/scp>\n                    Inhibition With Bimekizumab on Inflammatory and Structural Lesions in Axial Spondyloarthritis: Magnetic Resonance Imaging and Radiographic Outcomes From Two Phase 3 Studies and Their Open\u2010Label Extension"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-1755","authenticated-orcid":false,"given":"Walter P.","family":"Maksymowych","sequence":"first","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-9087","authenticated-orcid":false,"given":"Sofia","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Zuyderland Medical Center  Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-6015","authenticated-orcid":false,"given":"Denis","family":"Poddubnyy","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Schroeder Arthritis Institute University Health Network  Toronto Ontario Canada"},{"name":"Department of Gastroenterology, Infectious Diseases and Rheumatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenofon","family":"Baraliakos","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ruhrgebiet Herne Ruhr\u2010University Bochum  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G. 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