{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:00:25Z","timestamp":1790233225118,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R246\u2010A8822"],"award-info":[{"award-number":["R246\u2010A8822"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["24\u201010\u20100024"],"award-info":[{"award-number":["24\u201010\u20100024"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008628","name":"Institut for Klinisk Medicin, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A new algorithm enables the identification of patients with polymyalgia rheumatica (PMR) across health care sectors in Denmark. We estimated annual incidence rates from 2003 to 2024 and described the disease course, including the occurrence of late\u2010onset giant cell arteritis (GCA) and prednisolone or prednisone (PDN) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Danish nationwide, population\u2010based cohort study was conducted using data linked at the individual level. Cases were identified among people ages 50 years or older between January 1, 2003, and November 1, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 51,401 patients were identified, including 24,456 from primary care and 26,945 from secondary care. The age\u2010standardized incidence of PMR was 112 per 100,000 people (95% confidence interval [CI] 110.8\u2013112.8). During the study period, the incidence declined by 53% in primary health care and increased by 30% in secondary health care, resulting in an overall decline of 12%. Among patients with PMR, GCA occurred at a rate of 5.4 (95% CI 5.1\u20135.7) per 1,000 patient\u2010years, with a median of 68 days (interquartile range 10\u2013602) from PMR diagnosis. Overall, 28% and 22% of patients were still treated with PDN after 5 and 10 years, with a median daily dose of 4.1 and 5.5 mg of PDN, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The increasing incidence of PMR in secondary health care was exceeded by the declining incidence in primary health care. Most late\u2010onset GCA developed within the first year after PMR diagnosis. Many patients continued treatment with PDN for 5 to 10 years, indicating a need for earlier use of concomitant therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70337","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:35:20Z","timestamp":1789468520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Disease Course of Polymyalgia Rheumatica During Two Decades: A Nationwide Study Across Health Care Sectors in Denmark"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-1624","authenticated-orcid":false,"given":"Agnete Overgaard","family":"Donskov","sequence":"first","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-9174","authenticated-orcid":false,"given":"Ellen Margrethe","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-4328","authenticated-orcid":false,"given":"Annette","family":"De Thurah","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-5891","authenticated-orcid":false,"given":"Mette","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-3389","authenticated-orcid":false,"given":"Kresten Krarup","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34356"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.07.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213883"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac713"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaf367"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"112","article-title":"Synchronous variations of the incidence of temporal arteritis and polymyalgia rheumatica in different regions of Denmark; association with epidemics of Mycoplasma pneumoniae infection","volume":"23","author":"Elling P","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2026.2628455"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2023.2215044"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rkz033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152069"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae428"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05819-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207492"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.11.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303452"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225134"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S179083"},{"key":"e_1_2_7_20_1","volume-title":"BEFOLK2: Befolkningen 1. Januar efter k\u00f8n og alder (1901\u20102026) [PEOPLE2: The population 1 January by gender and age (1901\u20102026)]","author":"Danmarks Statistik","year":"2026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S258219"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_7_24_1","volume-title":"Yderregisteret [The outer register]","author":"Sundhedsdata\u2010Styrelsen"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S245060"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_2_7_27_1","volume-title":"FOLK1AM: Befolkningen den 1. i m\u00e5neden efter omr\u00e5de, k\u00f8n og alder (2021M10\u20102026M08) [FOLK1AM: The population of the 1st of the month by region, sex and age (2021M10\u20102026M08)]","author":"Danmarks Statistik","year":"2026"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2023.152260"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-024-06697-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071349"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaf614"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keag135"},{"key":"e_1_2_7_33_1","volume-title":"FOLK2: Befolkningen 1. januar efter k\u00f8n, alder, herkomst, oprindelsesland og statsborgerskab (1980\u20102026) [PEOPLE2: 1 January by sex, age, ancestry, country of origin and citizenship (1980\u20102026)]","author":"Danmarks Statistik","year":"2026"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:10:06Z","timestamp":1790230206000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":32,"alternative-id":["10.1002\/art.70337"],"URL":"https:\/\/doi.org\/10.1002\/art.70337","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"art.70337"}}