{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:51:37Z","timestamp":1791381097500,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE17\u20100036 KI\u2010PYRINA"],"award-info":[{"award-number":["ANR\u201021\u2010CE17\u20100036 KI\u2010PYRINA"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM R20141DD"],"award-info":[{"award-number":["FRM R20141DD"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Gout is the most common form of arthritis and results from reduced renal excretion of uric acid. A link between environmental pollution and hyperuricemia has been identified, but the underlying mechanisms remain unknown. Our aim was to determine whether the aryl hydrocarbon receptor (AHR), one of the main mediators of the toxicity of environmental pollutants, could be involved in uric acid homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Murine models based on pharmacological activation of AHR were used, as well as a mouse model with\n                      <jats:italic>Ahr<\/jats:italic>\n                      gene knockout, to analyze the impact of this receptor on renal uric acid excretion. Based on the initial results, additional mouse models were used to identify the links across AHR, gluconeogenesis, and renal uric acid excretion. A study was also conducted in four patients affected by glycogen storage disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Activation of AHR by dioxin\u2010like agonists decreases renal uric acid excretion, whereas its genetic deletion in mouse models increases renal uric acid excretion. AHR does not modulate renal uric acid transporters but alters gluconeogenic processes and lactate metabolism in hepatocytes. Lactate is exchanged for uric acid in the renal proximal tubule, reducing renal uric acid excretion. The study in patients confirms that gluconeogenesis is a major determinant of uric acid homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results highlight the major role of AHR and gluconeogenesis in the regulation of uric acid homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70344","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:18:12Z","timestamp":1789985892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aryl Hydrocarbon Receptor Regulates Uric Acid Homeostasis"],"prefix":"10.1002","author":[{"given":"Jeremy","family":"Zaworski","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellie","family":"Tang","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kervadec","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Do Cao","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Universit\u00e9 Paris\u2010Saclay, H\u00f4pital Antoine B\u00e9cl\u00e8re  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Bouderlique","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Nemazanyy","sequence":"additional","affiliation":[{"name":"Platform for Metabolic Analyses, Structure F\u00e9d\u00e9rative de Recherche Necker, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Haymann","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"},{"name":"Physiology unit, AP\u2010HP H\u00f4pital Tenon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang\u2010Korng","family":"Ea","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Denis Diderot Univ Paris  Paris France"},{"name":"Rheumatology Unit, AP\u2010HP, H\u00f4pital Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-4074","authenticated-orcid":false,"given":"Pascal","family":"Richette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Denis Diderot Univ Paris  Paris France"},{"name":"Rheumatology Unit, AP\u2010HP, H\u00f4pital Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Daudon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"},{"name":"Physiology unit, AP\u2010HP H\u00f4pital Tenon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-4790","authenticated-orcid":false,"given":"Thomas","family":"Bardin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Denis Diderot Univ Paris  Paris France"},{"name":"Rheumatology Unit, AP\u2010HP, H\u00f4pital Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6053-8975","authenticated-orcid":false,"given":"Emmanuel","family":"Letavernier","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM  Paris France"},{"name":"Physiology unit, AP\u2010HP H\u00f4pital Tenon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.155"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1756"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047948"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.06.040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23752"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209632"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120581109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318294ef68"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114525"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.12.030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-17883-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.03.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-2-27"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196502182720705"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196209132671102"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104643"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570090608"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv245"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050626"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2012.738457"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90021-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037103"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00822"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1380387"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1500137"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac109"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaa286"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.105108"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.237040"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","unstructured":"MarriD KanaO NaultR et al.Perturbation of space\u2010time gene expression of the liver lobule by 2 3 7 8\u2010tetrachlorodibenzo\u2010p\u2010dioxin. Abstract presented at: ASPET 2023 Annual Meeting; June2023. doi:https:\/\/doi.org\/10.1124\/jpet.122.280300","DOI":"10.1124\/jpet.122.280300"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1103593"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.131573"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186543"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1720827"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80339-7"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111681"},{"issue":"6","key":"e_1_2_6_39_1","first-page":"572","article-title":"Hyperuricemia in glycogen\u2010storage disease type 1","volume":"112","author":"Fine RN","year":"1966","journal-title":"AJDC"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq236"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2025.100422"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00372.2023"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4464"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072483"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.08.024"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:57:12Z","timestamp":1791377832000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":44,"alternative-id":["10.1002\/art.70344"],"URL":"https:\/\/doi.org\/10.1002\/art.70344","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2025-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"art.70344"}}