{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:48:05Z","timestamp":1791964085384,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Calcium pyrophosphate deposition (CPPD) disease is a heterogeneous condition and is frequently misdiagnosed due to the different clinical presentations and variable disease progression. Aim of this study is to identify clinical phenotypes of CPPD disease by integrating real\u2010world data from two data sets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the COLCHICORT trial and CHRONIC CPPD European observational cohort were analyzed. Multiple correspondence analysis (MCA) was employed to evaluate and visualize the association between modalities of quantitative variables. Hierarchical clustering on principal components were obtained from MCA\u2010identified clusters based on Ward agglomeration method with Euclidean distance. A bivariate analysis between clusters was then performed to characterize the clusters numerically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 134 patients were included in the analysis, resulting in four distinct clusters. Cluster 1 had predominantly monoarticular involvement, frequent recurrent flares, older age at onset, female prevalence, and high C\u2010reactive protein (CRP) levels. Cluster 2 also involved monoarticular cases but with persistent arthritis and onset after 60 years, with about half exhibiting elevated CRP. Cluster 3 included polyarticular cases, featuring persistent arthritis and lower CRP levels, whereas cluster 4 highlighted polyarticular involvement (spine and shoulder included) and primarily recurrent flares.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, by using for the first time a robust, data\u2010driven methodology based on real\u2010world data, two clusters similar to the EULAR phenotypes \u201cacute CPP crystal arthritis,\u201d and \u201cchronic CPP crystal inflammatory arthritis\u201d were confirmed, but in addition, two more clusters that do not correspond to any existing EULAR phenotypes were also identified. Due to the characteristics of the cohorts, the osteoarthritis plus CPPD cluster has not been explored.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art70345-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70345","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:08:42Z","timestamp":1789718922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Potential of Cluster Analysis in Identifying Disease Phenotypes in Calcium Pyrophosphate Deposition: Moving From Intuition to Insight"],"prefix":"10.1002","author":[{"given":"Greta","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Rheumatology Department IRCCS Ospedale Galeazzi Sant'Ambrogio  Milan Italy"},{"name":"Department of Biomedical and Clinical Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laur\u00e8ne","family":"Norberciak","sequence":"additional","affiliation":[{"name":"Research Department\u2010Biostatistics and Methodology H\u00f4pital Saint\u2010Philibert, Universit\u00e9 Catholique de Lille  Lomme France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sirotti","sequence":"additional","affiliation":[{"name":"Rheumatology Department IRCCS Ospedale Galeazzi Sant'Ambrogio  Milan Italy"},{"name":"Department of Biomedical and Clinical Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-4919","authenticated-orcid":false,"given":"Abhishek","family":"Abhishek","sequence":"additional","affiliation":[{"name":"University of Nottingham  Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-9055","authenticated-orcid":false,"given":"Mariano","family":"Andr\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dr Balmis General University Hospital\u2010Alicante Institute for Health and Biomedical Research, Miguel Hernandez University  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-8197","authenticated-orcid":false,"given":"Edoardo","family":"Cipolletta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Rheumatology Unit Polytechnic University of Marche  Jesi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Damart","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint\u2010Philibert Hospital Lille Catholic University  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Desbarbieux","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Boulogne\u2010sur\u2010Mer Hospital  Boulogne\u2010sur\u2010Mer France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Diez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dr Balmis General University Hospital\u2010Alicante Institute for Health and Biomedical Research, Miguel Hernandez University  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Ducoulombier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint\u2010Philibert Hospital Lille Catholic University  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-7475","authenticated-orcid":false,"given":"Hang\u2010Korng","family":"Ea","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lariboisi\u00e8re, APHP\u2010Nord, Service de Rhumatologie  Paris France"},{"name":"Bioscar UMR Inserm 1132 and Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Filippucci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Rheumatology Unit Polytechnic University of Marche  Jesi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jauffret","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Saint\u2010Philibert Hospital Lille Catholic University  Lille 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