{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:51:53Z","timestamp":1791186713539,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to provide a descriptive analysis of the 10\u2010year follow\u2010up data from the Clinical Remission in Peripheral Spondyloarthritis (CRESPA) study. Here, patients fulfilling the Assessment of Spondyloarthritis International Society peripheral spondyloarthritis (pSpA) classification criteria, with symptom duration \u226412 weeks, were randomized to golimumab 50 mg every four weeks or placebo. Our aims were to assess the proportion of patients in (drug\u2010free) clinical remission and identify baseline predictors of achieving (drug\u2010free) remission at 10\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients from the original CRESPA study were invited for a standardized evaluation 10 years after inclusion. Clinical remission was defined as the absence of swollen joints, enthesitis, or dactylitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 60 original patients, 49 were evaluated after a mean (\u00b1SD) of 10.5 (\u00b10.87) years. Of the patients, 81.6% (40 of 49) were in clinical remission, of whom 30.6% (15 of 49) achieved longstanding drug\u2010free remission. Remission was not linked to baseline characteristics like sex, age, HLA\u2010B27 positivity, psoriasis, or initial treatment allocation. Patients without psoriasis at baseline were significantly more likely to achieve drug\u2010free remission (odds ratio 9.1, 95% confidence interval 1.8\u201350), with 48.1% patients with nonpsoriatic pSpA (13 of 27) remaining in drug\u2010free remission. Health\u2010related quality of life and physical function were significantly better in patients in remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Remission induction with golimumab in patients with early pSpA enables achievement of sustained clinical remission in the majority of patients, with one\u2010third of patients attaining drug\u2010free remission. Strikingly, almost half of patients with nonpsoriatic pSpA remained in drug\u2010free remission. These findings strongly suggest that early, intensive treatment has the potential to achieve long\u2010term disease control, potentially leading to sustained drug\u2010free remission in a subset of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.70349","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:49:06Z","timestamp":1789987746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Free Remission in Early Peripheral Spondyloarthritis, Including Psoriatic Arthritis: 10\u2010Year Follow\u2010Up From the\n                    <scp>CRESPA<\/scp>\n                    Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9408-1158","authenticated-orcid":false,"given":"Caroline","family":"Damen","sequence":"first","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-8934","authenticated-orcid":false,"given":"Ann\u2010Sophie","family":"De Craemer","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"},{"name":"VIB Center for Inflammation Research Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-8547","authenticated-orcid":false,"given":"Casper","family":"Webers","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Maastricht University Medical Centre+  Maastricht the Netherlands"},{"name":"Care and Public Health Research Institute Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-974X","authenticated-orcid":false,"given":"Dirk","family":"Elewaut","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"},{"name":"VIB Center for Inflammation Research Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Varkas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"},{"name":"VIB Center for Inflammation Research Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"},{"name":"VIB Center for Inflammation Research Ghent University  Ghent 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