{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:53:56Z","timestamp":1791176036225,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp;amp; Rheumatology"],"DOI":"10.1002\/art.70352","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:02Z","timestamp":1790247062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From\n                    <scp>ADVOCATE<\/scp>\n                    to\n                    <scp>ADVOGATE<\/scp>\n                    : Is This the End of Avacopan?"],"prefix":"10.1002","author":[{"given":"Gavin B.","family":"Chapman","sequence":"first","affiliation":[{"name":"Edinburgh Kidney, Institute for Neuroscience and Cardiovascular Research, The Queen's Medical Research Institute University of Edinburgh  Edinburgh United Kingdom"},{"name":"Department of Renal Medicine Royal Infirmary of Edinburgh  Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Pugh","sequence":"additional","affiliation":[{"name":"Edinburgh Kidney, Institute for Neuroscience and Cardiovascular Research, The Queen's Medical Research Institute University of Edinburgh  Edinburgh United Kingdom"},{"name":"Department of Renal Medicine Royal Infirmary of Edinburgh  Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-6603","authenticated-orcid":false,"given":"Neeraj","family":"Dhaun","sequence":"additional","affiliation":[{"name":"Edinburgh Kidney, Institute for Neuroscience and Cardiovascular Research, The Queen's Medical Research Institute University of Edinburgh  Edinburgh United Kingdom"},{"name":"Department of Renal Medicine Royal Infirmary of Edinburgh  Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013020143"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023386"},{"key":"e_1_2_3_3_2","doi-asserted-by":"crossref","unstructured":"Erratum in:N Engl J Med2024;390:388. doi:https:\/\/doi.org\/10.1056\/NEJMx230010","DOI":"10.1056\/NEJMx230010"},{"key":"e_1_2_3_3_3","doi-asserted-by":"crossref","unstructured":"Retraction in:N Engl J MedPublished online June 29 2026. doi:https:\/\/doi.org\/10.1056\/NEJMe2608684","DOI":"10.1056\/NEJMe2608684"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2033621"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2608684"},{"key":"e_1_2_3_6_1","volume-title":"Proposal to withdraw marketing approval; notice of opportunity for a hearing","author":"H\u00f8eg TB","year":"2026"},{"key":"e_1_2_3_7_1","volume-title":"Amgen statement on FDA data submission for TAVNEOS (avacopan)","author":"Amgen","year":"2026"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.103753"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez001"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.04.030"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.05.041"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.01.039"},{"key":"e_1_2_3_13_1","volume-title":"FDA approves add\u2010on drug for adults with rare form of blood vessel inflammation","author":"US Food and Drug Administration","year":"2021"},{"key":"e_1_2_3_14_1","volume-title":"FDA identifies cases of serious liver injury in patients taking TAVNEOS (avacopan) for severe active anti\u2010neutrophil cytoplasmic autoantibody (ANCA)\u2010associated vasculitis","author":"US Food and Drug Administration","year":"2026"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.70304"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-025-00456-4"},{"key":"e_1_2_3_17_1","volume-title":"FDA commissioner and chief scientist announce decision to withdraw approval of Makena","author":"US Food and Drug Administration","year":"2023"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2011.12.001"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105289\u20103"},{"key":"e_1_2_3_19_2","doi-asserted-by":"crossref","unstructured":"Erratum in:Intensive Care Med2021;47:264. doi:https:\/\/doi.org\/10.1007\/s00134-020-06270-5","DOI":"10.1007\/s00134-020-06270-5"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11948-015-9680-y"},{"key":"e_1_2_3_21_1","volume-title":"European Commission (EC) adopts decision to revoke marketing authorisation for TAVNEOS (avacopan) in the European Union and European Economic Area countries","author":"CSL Vifor","year":"2026"},{"key":"e_1_2_3_22_1","volume-title":"MHRA review of the benefits and risks of avacopan","author":"Medicines and Healthcare Products Regulatory Agency","year":"2026"},{"key":"e_1_2_3_23_1","volume-title":"Investigation results on avacopan","author":"Pharmaceutical and Medical Devices Agency","year":"2026"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444560"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.70352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.70352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:48:01Z","timestamp":1791175681000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.70352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":26,"alternative-id":["10.1002\/art.70352"],"URL":"https:\/\/doi.org\/10.1002\/art.70352","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"art.70352"}}