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To implement inclusive learning environments and address the shortage of learning materials for both sighted and visually impaired students, this work aimed to design, apply, and evaluate learning tools based on digital technologies, using the principles of Educational Design Research. 3D models representing cell membranes were created and embedded in an online virtual reality (VR) environment equipped with audio descriptions and an innovative color\u2010changing interface. Models were also optimized for embedding in an augmented reality (AR) environment on social media. Notably, our work is the first to create such an extensive library of both animate and static VR and AR\u2010based material, covering the structural composition of the membrane, transport mechanisms, and detailed representations of membrane specializations. Additionally, we provided, in an unprecedented way, a systematic description of our results to serve as a roadmap for easy replication and adaptation within the educational community, fostering the creation of new learning tools and approaches. Evaluation of learning tools was conducted with sighted and visually impaired students from biological and health\u2010related undergraduate courses, as well as experienced and early\u2010career Cell Biology teachers. 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