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These two orientations lead to diastereomeric products, thus allowing for unambiguous correlation between product configuration and transition\u2010state geometry. As steric bias is minimal, the product distribution should reflect the intrinsic preferences for reactant geometry in the transition state. Cyclizations of the model compound showed a modest preference for reaction via an antiperiplanar (open transition state) orientation of reactants in the presence of a wide range of Lewis acids (TiCl<jats:sub>4<\/jats:sub>, SnCl<jats:sub>4,<\/jats:sub> SnCl<jats:sub>2<\/jats:sub>, BF<jats:sub>3<\/jats:sub>\u22c5OEt<jats:sub>2<\/jats:sub>, TMSBr, trityl perchlorate, EtAlCl<jats:sub>2<\/jats:sub>) and triflic acid. The cyclizations promoted by tin(II) salts were <jats:italic>syn<\/jats:italic>\u2010selective and dependent on the nature of the counterion. Fluoride ion promoted reactions were <jats:italic>anti<\/jats:italic>\u2010selective and were independent of the nature of the cation.<\/jats:p>","DOI":"10.1002\/asia.200700300","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T11:18:47Z","timestamp":1195471127000},"page":"327-341","source":"Crossref","is-referenced-by-count":28,"title":["Investigations into Transition\u2010State Geometry in the Mukaiyama Directed Aldol Reaction"],"prefix":"10.1002","volume":"3","author":[{"given":"Scott\u2005E.","family":"Denmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wheeseong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,29]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"Challenges in Synthetic Organic Chemistry","author":"Mukaiyama T.","year":"1994"},{"key":"e_1_2_7_2_2","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1973.1011"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1975.989"},{"key":"e_1_2_7_5_2","first-page":"1","volume":"16","author":"Nielsen A.","year":"1968","journal-title":"Org. 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