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C\uf8ffH bond\u2010activation processes provide a straightforward and atom\u2010economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C\uf8ffH activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C\uf8ffN bond precursor. As a consequence, a variety of nitrogen\u2010containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide\u2010directed tandem C\uf8ffC\/C\uf8ffN bond\u2010formation process through C\uf8ffH activation. 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