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Amylin is a polypeptide that is co\u2010secreted with insulin from islet beta\u2010cells and is implicated in fibril formation. In this study, rat amylin was used, which does not undergo aggregation. The polypeptide underwent an interfacial transfer process, from water to the gelled organic phase, under applied potential stimulation. Cyclic voltammetry revealed steady\u2010state forward and peak\u2010shaped reverse voltammograms, which were consistent with diffusion\u2010controlled water\u2010to\u2010organic transfer and thin\u2010film stripping or desorptive back\u2010transfer. The diffusion\u2010controlled forward current was greater when amylin was present in an acidic aqueous phase than when it was present in an aqueous phase at physiological pH; this reflects the greater charge on the polypeptide under acidic conditions. The amylin transfer current was concentration dependent over the range 2\u201310\u2005\u03bc<jats:sc>M<\/jats:sc>, at both acidic and physiological pH. At physiological pH, amylin was selectively detected in the presence of a protein mixture, which illustrated the bioanalytical possibilities for this electrochemical behavior.<\/jats:p>","DOI":"10.1002\/asia.201300215","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T15:27:53Z","timestamp":1370618873000},"page":"2096-2101","source":"Crossref","is-referenced-by-count":9,"title":["Ion\u2010Transfer Electrochemistry of Rat Amylin at the Water\u2013Organogel Microinterface Array and Its Selective Detection in a Protein Mixture"],"prefix":"10.1002","volume":"8","author":[{"given":"Eva","family":"Alvarez\u2005de\u2005Eulate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Newsholme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien W. 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