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Herein, we report that the use of barbital (Bar) instead of CA for the self\u2010assembly with Zn<jats:sub>2<\/jats:sub>L<jats:sup>1<\/jats:sup> and Cu<jats:sup>2+<\/jats:sup> induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex <jats:bold>6\u2009a<\/jats:bold>, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that <jats:bold>6\u2009a<\/jats:bold> also accelerates the hydrolysis of MNP, similarly to <jats:bold>3<\/jats:bold>. Moreover, inspired by the crystal structure of <jats:bold>6\u2009a<\/jats:bold>, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu<jats:sub>2<\/jats:sub>(\u03bc\u2010OH)<jats:sub>2<\/jats:sub> catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP).<\/jats:p>","DOI":"10.1002\/asia.201402513","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T18:42:54Z","timestamp":1406745774000},"page":"2831-2841","source":"Crossref","is-referenced-by-count":13,"title":["Supramolecular Phosphatases Formed by the Self\u2010Assembly of the Bis(Zn<sup>2+<\/sup>\u2013Cyclen) Complex, Copper(II), and Barbital Derivatives in 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