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Notably, this design strategy was first employed for the development of fluorescent CN<jats:sup>\u2212<\/jats:sup> probes. The experimental details showed that probe <jats:bold>1\u2009a<\/jats:bold> exhibited a fluorescence turn\u2010on response to CN<jats:sup>\u2212<\/jats:sup>, whereas other anions, biological thiols, and hydrogen sulfide gave almost no interference. The detection limit of probe <jats:bold>1\u2009a<\/jats:bold> for CN<jats:sup>\u2212<\/jats:sup> was found to be 0.12\u2005\u03bc<jats:sc>M<\/jats:sc>. The sensing reaction product of <jats:bold>1\u2009a<\/jats:bold> with CN<jats:sup>\u2212<\/jats:sup> was characterized by NMR spectroscopy and mass spectrometry. TD\u2010DFT calculations demonstrated that the formed cyano group drives the intramolecular charge transfer (ICT) process from coumarin dye to the cyano group and thus the original strong ICT from the coumarin dye to the 3\u2010position pyridyl vinyl ketone substituent is weakened, which results in recovery of coumarin fluorescence. The practical utility of <jats:bold>1\u2009a<\/jats:bold> was also examined. By fabricating paper strips, probe <jats:bold>1\u2009a<\/jats:bold> can be used as a simple tool to detect CN<jats:sup>\u2212<\/jats:sup> in field measurements. Moreover, probe <jats:bold>1\u2009a<\/jats:bold> has been successfully applied for quantitative detection of endogenous CN<jats:sup>\u2212<\/jats:sup> from cassava root.<\/jats:p>","DOI":"10.1002\/asia.201402765","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T11:42:56Z","timestamp":1408707776000},"page":"3291-3298","source":"Crossref","is-referenced-by-count":35,"title":["Reaction\u2010Based Fluorescent Probe for Detection of Endogenous Cyanide in Real Biological Samples"],"prefix":"10.1002","volume":"9","author":[{"given":"Lingliang","family":"Long","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulin","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","volume-title":"Cyanide Toxicity","author":"Kulig K. 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