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The two isomeric forms (<jats:bold>BISP<\/jats:bold>\u2194<jats:bold>BIMC<\/jats:bold>) were shown to be highly selective and sensitive to CN<jats:sup>\u2212<\/jats:sup> among the ten anions studied in aqueous HEPES buffer, as shown by fluorescence and absorption spectroscopy and even by visual color changes, with a detection limit of 1.7\u2005\u03bc<jats:sc>M<\/jats:sc> for <jats:bold>BIMC<\/jats:bold>. The reaction of CN<jats:sup>\u2212<\/jats:sup> with <jats:bold>BIMC<\/jats:bold> was monitored by <jats:sup>1<\/jats:sup>H\u2005NMR spectroscopy, high\u2010resolution mass spectrometry (HRMS), UV\/Vis measurements, and fluorescence spectroscopy in HEPES buffer of pH\u20057.4. TDDFT calculations were performed in order to correlate the electronic properties of the chemosensor with its cyanide complex. Further, titration against thiophilic metal ions like Au<jats:sup>3+<\/jats:sup>, Cu<jats:sup>2+<\/jats:sup>, Ag<jats:sup>+<\/jats:sup>, and Hg<jats:sup>2+<\/jats:sup> with [<jats:bold>BIMC\u2010CN<\/jats:bold>] in situ showed that it acts as a secondary recognition ensemble toward Au<jats:sup>3+<\/jats:sup> and Cu<jats:sup>2+<\/jats:sup> by switch\u2010on fluorescence. In addition, a reversible logic\u2010gate property of <jats:bold>BIMC<\/jats:bold> has been demonstrated through a feedback loop in the presence of CN<jats:sup>\u2212<\/jats:sup> and Au<jats:sup>3+<\/jats:sup> ions, respectively. Furthermore, the use of <jats:bold>BIMC<\/jats:bold> to detect CN<jats:sup>\u2212<\/jats:sup> in live cells by fluorescence imaging has also been demonstrated. Notably, test strips based on <jats:bold>BIMC<\/jats:bold> were fabricated, which could serve as convenient and efficient CN<jats:sup>\u2212<\/jats:sup> test kits.<\/jats:p>","DOI":"10.1002\/asia.201402923","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T17:59:02Z","timestamp":1414432742000},"page":"3623-3632","source":"Crossref","is-referenced-by-count":33,"title":["Unique Fluorogenic Ratiometric Fluorescent Chemodosimeter for Rapid Sensing of CN<sup>\u2212<\/sup> in Water"],"prefix":"10.1002","volume":"9","author":[{"given":"Ajit Kumar","family":"Mahapatra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalipada","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saikat Kumar","family":"Manna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajkishor","family":"Maji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitrangada Das","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bholanath","family":"Pakhira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabyasachi","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5459.1737"},{"key":"e_1_2_6_2_2","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","unstructured":"K.\u2005W. 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