{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:43:10Z","timestamp":1791463390281,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A dichloromethane extract of the stems of <jats:italic>Alangium salviifolium<\/jats:italic> afforded twelve cardinane sesquiterpenes, seven of which are new alangenes A\u2010G (<jats:bold>1<\/jats:bold>\u2013<jats:bold>7<\/jats:bold>) and five known compounds (<jats:bold>8<\/jats:bold>\u2013<jats:bold>12<\/jats:bold>). Their structures were elucidated on the basis of spectroscopic techniques including UV, IR, and NMR spectroscopies, and mass spectrometry. Most of the tested compounds exhibited very potent aromatase inhibition properties, especially in the case of the cardinane sesquiterpenes <jats:bold>1<\/jats:bold>, <jats:bold>5<\/jats:bold>\u2013<jats:bold>8<\/jats:bold>, and <jats:bold>10<\/jats:bold> (IC<jats:sub>50<\/jats:sub> values of 0.09, 0.13, 0.30, 0.06, 2.05, and 1.19\u2005\u03bc<jats:sc>M<\/jats:sc>, respectively), which are significantly better than that of the positive control (ketoconazole, IC<jats:sub>50<\/jats:sub> of 2.4\u2005\u03bc<jats:sc>M<\/jats:sc>). Compounds <jats:bold>1<\/jats:bold> and <jats:bold>4<\/jats:bold> exhibited selective cytotoxicity against the MOLT\u20103 cancer cell line with IC<jats:sub>50<\/jats:sub> values of 7.9 and 2.1\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>, respectively.<\/jats:p>","DOI":"10.1002\/asia.201403253","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T16:02:58Z","timestamp":1422892978000},"page":"910-914","source":"Crossref","is-referenced-by-count":15,"title":["Bioactive Cardinane Sesquiterpenes from the Stems of <i>Alangium salviifolium<\/i>"],"prefix":"10.1002","volume":"10","author":[{"given":"Phanruethai","family":"Pailee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilailak","family":"Prachyawarakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somsak","family":"Ruchirawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulabhorn","family":"Mahidol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/np9601420"},{"key":"e_1_2_6_2_2","first-page":"24","volume-title":"Medicinal Plants in Thailand, Vol.\u2005I","author":"Saralamp P.","year":"1996"},{"key":"e_1_2_6_3_2","unstructured":"\u00a0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.05.070"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00417-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0000163"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50122a011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)80016-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)81388-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)92835-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201100423"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(96)00279-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)80061-K"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)62022-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/np049847p"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0301238"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00363a018"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9801566"},{"key":"e_1_2_6_19_2","first-page":"214","volume-title":"Chapter 13\u2014\u201cBreast Cancer Genomics\u201d In Cancer Genomics","author":"Bydoun M.","year":"2014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.92"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2000.4729"},{"key":"e_1_2_6_22_2","first-page":"936","volume":"47","author":"Carmichael J.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_6_24_2","volume-title":"Mammalian cell culture: essential techniques","author":"Doyle A.","year":"1997"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fasia.201403253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.201403253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:18:19Z","timestamp":1759951099000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.201403253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/asia.201403253"],"URL":"https:\/\/doi.org\/10.1002\/asia.201403253","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}