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In order to visualize the endogenous in situ production of H<jats:sub>2<\/jats:sub>S in living cells in real time, here we developed multi\u2010fluorinated azido coumarins as fluorescent probes for the rapid and selective detection of biological H<jats:sub>2<\/jats:sub>S. Kinetic studies indicated that an increase in fluorine substitution leads to an increased rate of H<jats:sub>2<\/jats:sub>S\u2010mediated reduction reaction, which is also supported by our theoretical calculations. To our delight, tetra\u2010fluorinated coumarin <jats:bold>1<\/jats:bold> could react with H<jats:sub>2<\/jats:sub>S fast (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>\u22481\u2005min) and selectively, which could be further used for continuous enzymatic assays and for visualization of intracellular H<jats:sub>2<\/jats:sub>S. Bioimaging results obtained with <jats:bold>1<\/jats:bold> revealed that <jats:sc>d<\/jats:sc>\u2010Cys could induce a higher level of endogenous H<jats:sub>2<\/jats:sub>S production than <jats:sc>l<\/jats:sc>\u2010Cys in a time\u2010dependent manner in living cell.<\/jats:p>","DOI":"10.1002\/asia.201500940","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T03:38:50Z","timestamp":1442547530000},"page":"68-71","source":"Crossref","is-referenced-by-count":20,"title":["Multi\u2010Fluorinated Azido Coumarins for Rapid and Selective Detection of Biological H<sub>2<\/sub>S in Living Cells"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhentao","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology (BUCT)  15 Beisanhuan East Road, Chaoyang District Beijing 100029 P. R. 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