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Development of fluorescent probes for highly selective and sensitive detection of H<jats:sub>2<\/jats:sub>S is necessary. We show here that dual\u2010reactable fluorescent H<jats:sub>2<\/jats:sub>S probes could react with higher selectivity than single\u2010reactable probes. One of the dual\u2010reactable probes gives more than 4000\u2010fold turn\u2010on response when reacting with H<jats:sub>2<\/jats:sub>S, the largest response among fluorescent H<jats:sub>2<\/jats:sub>S probes reported thus far. In addition, the probe could be used for high\u2010throughput enzymatic assays and for the detection of Cys\u2010induced H<jats:sub>2<\/jats:sub>S in cells and in zebrafish. 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