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The key step is a direct construction of the highly strained 13\u2010membered macrocycle of GKK1032A<jats:sub>2<\/jats:sub> by an intramolecular nucleophilic aromatic substitution (S<jats:sub>N<\/jats:sub>Ar) reaction. This is the first successful example of construction of a macrocycle with an aryl ether linkage utilizing an intramolecular S<jats:sub>N<\/jats:sub>Ar reaction of an (<jats:italic>\u03b7<\/jats:italic><jats:sup>6<\/jats:sup>\u2010arene)chromium complex.<\/jats:p>","DOI":"10.1002\/asia.201601728","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T22:23:01Z","timestamp":1486592581000},"page":"628-632","source":"Crossref","is-referenced-by-count":15,"title":["Total Synthesis of GKK1032A<sub>2<\/sub> via Direct 13\u2010Membered Macrocyclization Using a Nucleophilic Aromatic Substitution of an (\u03b7<sup>6<\/sup>\u2010Arene)Chromium Complex"],"prefix":"10.1002","volume":"12","author":[{"given":"Hayato","family":"Sugata","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ode","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Karoji","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Baba","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kato","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiju","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Tsubogo","sequence":"additional","affiliation":[{"name":"Division of Fusion of Regenerative Medicine with DDS Research Institute for Science and Technology (RIST) Tokyo University of Science  2641 Yamazaki Noda Chiba 278-8510 Japan"},{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-1605","authenticated-orcid":false,"given":"Hiromi","family":"Uchiro","sequence":"additional","affiliation":[{"name":"Division of Fusion of Regenerative Medicine with DDS Research Institute for Science and Technology (RIST) Tokyo University of Science  2641 Yamazaki Noda Chiba 278-8510 Japan"},{"name":"Faculty of Pharmaceutical Sciences Tokyo University of Science  2641 Yamazaki Noda Chiba 278\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","unstructured":"F.Koizumi A.Hasegawa K.Ando T.Ogawa M.Hara M.Yoshida Jpn. 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