{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:24:10Z","timestamp":1768339450775,"version":"3.49.0"},"reference-count":72,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372248"],"award-info":[{"award-number":["21372248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21532002"],"award-info":[{"award-number":["21532002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21672244"],"award-info":[{"award-number":["21672244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2017,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relative and absolute configuration of neomaclafungins were impossible to establish by spectroscopic analyses alone because of the lack of exploitable <jats:sup>1<\/jats:sup>H\u2010<jats:sup>1<\/jats:sup>H couplings and nOes between the upper and the lower subunits. This very difficult task now is finally completed by an enantioselective total synthesis of neomaclafungin A (revised) and its diastereomer (reported). The results also provided a key reference for the complete structures for other neomaclafungins and the long\u2010known closely related natural product maclafungin.<\/jats:p>","DOI":"10.1002\/asia.201700950","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T21:44:49Z","timestamp":1499723089000},"page":"2211-2215","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and Configuration of Neomaclafungin A"],"prefix":"10.1002","volume":"12","author":[{"given":"Shijun","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioorganic and Natural Products Chemistry Collaborative Innovative Center for Chemistry and Life Sciences Shanghai Institute of Organic Chemistry and the University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-5401","authenticated-orcid":false,"given":"Yikang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioorganic and Natural Products Chemistry Collaborative Innovative Center for Chemistry and Life Sciences Shanghai Institute of Organic Chemistry and the University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/np300719g"},{"key":"e_1_2_2_3_2","unstructured":"Two full structures were given for neomaclafungins in ref. 1a (both were incorrect); the correct relative configuration for the upper fragment (with absolute configuration opposite to that proven in this work) was only found in the truncated structure in Figure\u20052 therein;"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.022"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.11.157"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201304039"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00838-2"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00372a030"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo001767c"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo980982e"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200901373"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00279a042"},{"key":"e_1_2_2_14_1","unstructured":"At ambient temperature the reaction never went to completion."},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)00725-1"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol302570k"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00275a029"},{"key":"e_1_2_2_18_1","unstructured":"\u00a0"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9716721"},{"key":"e_1_2_2_20_2","first-page":"1371","author":"Crimmins M. 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The spiroketal formation was also retarded by the C-24 -(CH2)3OPMB (compared with the facile synth. of the spiroketal in oligomycins)."},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00077a054"},{"key":"e_1_2_2_29_1","unstructured":"\u00a0"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00278a057"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9708755"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol100290a"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200702735"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200702735"},{"key":"e_1_2_2_34_1","unstructured":"\u00a0"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)90389-2"},{"key":"e_1_2_2_36_2","unstructured":"cf. ref. 3c;"},{"key":"e_1_2_2_37_2","unstructured":"TEMPO oxidation of25failed."},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00283a046"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.52.1989"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)90593-9"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.06.080"},{"key":"e_1_2_2_42_1","unstructured":"\u00a0"},{"key":"e_1_2_2_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja055967n"},{"key":"e_1_2_2_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00060a054"},{"key":"e_1_2_2_45_1","unstructured":"\u00a0"},{"key":"e_1_2_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00254a014"},{"key":"e_1_2_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)80728-6"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.09.015"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.72.2501"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(99)00556-6"},{"key":"e_1_2_2_51_1","unstructured":"\u00a0"},{"key":"e_1_2_2_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9056163"},{"key":"e_1_2_2_53_2","unstructured":"Reduction using Et2BOMe\/Li(or Na)BH4\/-78\u2009\u00b0C on 10\u2005mg scale led to a 2:1 mixture of35andepi-35. 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DIBAL-H\/-98\u2009\u00b0C gave asyndiol with the TBS migrated."},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00170a070"},{"key":"e_1_2_2_55_1","unstructured":"\u00a0"},{"key":"e_1_2_2_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00158a056"},{"key":"e_1_2_2_57_2","unstructured":"Use of Na(or Li)BH4\/THF-MeOH (or H2O) led to partial racemization at the C-4."},{"key":"e_1_2_2_58_1","unstructured":"\u00a0"},{"key":"e_1_2_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199520391"},{"key":"e_1_2_2_59_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19951071818"},{"key":"e_1_2_2_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar00059a002"},{"key":"e_1_2_2_61_1","unstructured":"\u00a0"},{"key":"e_1_2_2_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo801794s"},{"key":"e_1_2_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403542"},{"key":"e_1_2_2_63_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201403542"},{"key":"e_1_2_2_64_1","unstructured":"Use of4\u2032in Suzuki coupling with5led to <10\u2009% yields and removal of PMB at a later stage was unfeasible. 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