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We herein report that a luminescent metal complex <jats:bold>LD\u2010TPZn<\/jats:bold> can specifically image LDs in adipose cells and tissue using one\u2010 or two\u2010photon fluorescence microscopy. Importantly, <jats:bold>LD\u2010TPZn<\/jats:bold> exhibited higher specificity to LDs than the commercial dyes Nile Red and Bodipy 493\/503, probably due to different cellular uptake pathways, that is, clathrin\u2010mediated endocytosis and non\u2010selectively passive diffusion, respectively. More importantly, <jats:bold>LD\u2010TPZn<\/jats:bold> can be applied as a two\u2010photon LD probe to image adipose tissue, one of the most challengeable tissues for traditional one\u2010photon fluorescence microscope imaging due to the strong light scattering. Most importantly, <jats:bold>LD\u2010TPZn<\/jats:bold> can be used to monitor LD growth during adipogenesis of preadipocytes, which is highly desirable to unravel the relationship between LD homeostasis and metabolic diseases.<\/jats:p>","DOI":"10.1002\/asia.201701010","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T08:02:47Z","timestamp":1501833767000},"page":"2533-2538","source":"Crossref","is-referenced-by-count":26,"title":["Precise Labeling and Tracking of Lipid Droplets in Adipocytes Using a Luminescent ZnSalen Complex"],"prefix":"10.1002","volume":"12","author":[{"given":"Juan","family":"Tang","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular Engineering Peking University  Beijing 100871 P.R. 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