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Herein, we report the design and synthesis of a new series of far\u2010red\/near\u2010infrared (FR\/NIR) fluorescent AIEgens that consist of methoxy\u2010substituted tetraphenylethene (TPE) as the electron\u2010donating moiety, (1,3\u2010dimethyl)barbituric acid as the electron\u2010withdrawing moiety, and different \u03c0\u2010bridge units. As compared to benzene or 3,4\u2010ethylenedioxythiophene, using thiophene as the \u03c0\u2010conjugation unit between the donor and acceptor results in a relatively higher absolute fluorescence quantum yield (14.5\u2009%) in water when formulating the corresponding AIEgens into nanoparticles (AIE dots) with an amphiphilic co\u2010polymer as the doping matrix. The highly FR\/NIR\u2010emissive thiophene\u2010based AIE dots are demonstrated to be potent for intraoperative detection of pulmonary metastatic tumors, particularly the micro\u2010sized ones, with excellent signal\u2010to\u2010background ratio.<\/jats:p>","DOI":"10.1002\/asia.201801660","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T06:29:43Z","timestamp":1544682583000},"page":"871-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Far\u2010Red\/Near\u2010Infrared Emissive (1,3\u2010Dimethyl)barbituric Acid\u2010Based AIEgens for High\u2010Contrast Detection of Metastatic Tumors in the Lung"],"prefix":"10.1002","volume":"14","author":[{"given":"Heqi","family":"Gao","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Siences Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Bao","sequence":"additional","affiliation":[{"name":"Tianjin Stomatological Hospital Hospital of Stomatology Nankai University  Tianjin 300041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxin","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Siences Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Siences Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglu","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Siences Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Urology Tianjin First Central Hospital  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Tianjin Stomatological Hospital Hospital of Stomatology Nankai University  Tianjin 300041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Tianjin First Central Hospital  Tianjin 300192 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6510","authenticated-orcid":false,"given":"Dan","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials Ministry of Education, and College of Life Siences Nankai University  Tianjin 300071 China"},{"name":"State Key Laboratory of Luminescent Materials and Devices South China University of Technology  Guangzhou 510640 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4476"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04222-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-018-0221-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00242"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00908E"},{"key":"e_1_2_6_7_1","unstructured":"\u00a0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.123"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06777"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2468"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400821111"},{"key":"e_1_2_6_12_1","unstructured":"\u00a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.055"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR00888K"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05113-8"},{"key":"e_1_2_6_16_1","unstructured":"\u00a0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.9899"},{"key":"e_1_2_6_18_2","first-page":"1072","volume":"4","author":"Olson M. 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