{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:31:26Z","timestamp":1768717886994,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21631001"],"award-info":[{"award-number":["21631001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21571002"],"award-info":[{"award-number":["21571002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21671001"],"award-info":[{"award-number":["21671001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2019,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A theranostic platform with integrated diagnostic and therapeutic functions as well as specific targeted and controlled combination therapy to enhance treatment efficacy is of great importance for a wide range of biomedical applications. Here, we first attempted to develop biocompatible hyaluronic acid (HA)\u2013glutathione (GSH) conjugate stabilized gold nanoclusters (GNCs) combined with graphene oxide (GO), accompanied by loading 5\u2010fluorouracil (5FU), as a novel theranostic platform (HG\u2010GNCs\/GO\u20105FU, HG refers to HA\u2010GSH). Multifunctional HG\u2010GNCs possessed excellent fluorescence, photosensitivity and specific targeting ability to the cancer cells while their fluorescence and singlet oxygen generation could be strongly inhibited by GO and then effectively restored by lysosomal hyaluronidase in tumor cells. The sustained and complete release of 5FU from HG\u2010GNCs\/GO could also be stimulated successively by enzymatic degradation of HA and light\u2010induced heat effect of GO under laser irradiation so that turn\u2010on cell imaging\u2010assisted synergistic therapeutic strategies associated with triple enzyme\/light\u2010controlled chemo\/photothermal\/photodynamic therapy could be achieved at the same time, reducing greatly the side effects of materials to normal cells. Our study presents a novel strategy to combine targeting and bioimaging with triple therapies to enhance the antitumor effect.<\/jats:p>","DOI":"10.1002\/asia.201900153","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T07:54:25Z","timestamp":1551686065000},"page":"1418-1423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Engineered Targeted Hyaluronic Acid\u2013Glutathione\u2010Stabilized Gold Nanoclusters\/Graphene Oxide\u20135\u2010Fluorouracil as a Smart Theranostic Platform for Stimulus\u2010Controlled Fluorescence Imaging\u2010Assisted Synergetic Chemo\/Phototherapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Physical Science and Information Technology Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Collaborative innovation center of modern bio-manufacture Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Collaborative innovation center of modern bio-manufacture Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Collaborative innovation center of modern bio-manufacture Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-0494","authenticated-orcid":false,"given":"Yuhua","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Collaborative innovation center of modern bio-manufacture Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manzhou","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Collaborative innovation center of modern bio-manufacture Anhui University  Hefei 230601 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc200151q"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.060"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm33737a"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150302120517"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn402199g"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201400914"},{"key":"e_1_2_2_9_1","unstructured":"\u00a0"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2011.04.007"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4TC01489H"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500235"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201401658"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.11.2260"},{"key":"e_1_2_2_15_1","unstructured":"\u00a0"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10020441"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200901672"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm15946e"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201502650"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC00685G"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.07.035"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac303747t"},{"key":"e_1_2_2_23_1","unstructured":"\u00a0"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708319200"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.015"},{"key":"e_1_2_2_26_2","first-page":"1351021","volume":"27","author":"Wan L.","year":"2016","journal-title":"Nanotechnology"},{"key":"e_1_2_2_27_1","unstructured":"\u00a0"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl015565n"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR08557E"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja055064u"},{"key":"e_1_2_2_31_1","unstructured":"\u00a0"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b07326"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.017"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102722z"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.25719"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.016"},{"key":"e_1_2_2_37_1","first-page":"2147031","volume":"131","author":"Simms G. A.","year":"2009","journal-title":"Chem. Phys."},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2014.12.026"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503873"},{"key":"e_1_2_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200503873"},{"key":"e_1_2_2_40_1","unstructured":"\u00a0"},{"key":"e_1_2_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500273"},{"key":"e_1_2_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506154"},{"key":"e_1_2_2_42_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201506154"},{"key":"e_1_2_2_43_1","unstructured":"\u00a0"},{"key":"e_1_2_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7832"},{"key":"e_1_2_2_45_2","first-page":"778","volume":"57","author":"Pham H. T.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_2_46_1","unstructured":"\u00a0"},{"key":"e_1_2_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.02.010"},{"key":"e_1_2_2_48_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0061"},{"key":"e_1_2_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.01.046"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fasia.201900153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.201900153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.201900153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.201900153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:56:25Z","timestamp":1759938985000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.201900153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5,2]]}},"alternative-id":["10.1002\/asia.201900153"],"URL":"https:\/\/doi.org\/10.1002\/asia.201900153","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2019-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}