{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:33:55Z","timestamp":1772080435322,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2019,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report an efficient synthetic strategy to diverse hydantoins and thiohydantoins involving a three\u2010component reaction with the aid of deep eutectic solvent. Here, <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010dimethyl urea and <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010dimethyl thiourea play a dual role as reactant and reaction medium along with <jats:sc>l<\/jats:sc>\u2010(+)\u2010tartaric acid. The three\u2010component reaction provides an easy access to 5\u2010amino\u20101,3\u2010dialkyl\u2010substituted hydantoins and thiohydantoins in good yields.<\/jats:p>","DOI":"10.1002\/asia.201900744","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T09:06:52Z","timestamp":1565082412000},"page":"3188-3197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-0233","authenticated-orcid":false,"given":"Sambasivarao","family":"Kotha","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  Bombay Powai Mumbai 400 076 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  Bombay Powai Mumbai 400 076 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-1815","authenticated-orcid":false,"given":"Vikas R.","family":"Aswar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  Bombay Powai Mumbai 400 076 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol047368b"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00304940409356627"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja991160h"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/np070246i"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0503698"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/np900437y"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm401604x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00847"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm300249m"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00095"},{"key":"e_1_2_7_14_1","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02073"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201601305"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201100862"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-1124(77)80492-9"},{"key":"e_1_2_7_19_1","unstructured":"\u00a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0032-9592(93)85027-D"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1219149"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/prac.19341410102"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01429a017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.190804101255"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60145a001"},{"key":"e_1_2_7_26_1","first-page":"373","volume":"71","author":"Ugi I.","year":"1959","journal-title":"Angew. Chem."},{"key":"e_1_2_7_27_1","unstructured":"\u00a0"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja802242h"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990517)38:10<1454::AID-ANIE1454>3.0.CO;2-D"},{"key":"e_1_2_7_29_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19990517)111:10<1562::AID-ANGE1562>3.0.CO;2-W"},{"key":"e_1_2_7_30_1","unstructured":"\u00a0"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(03)00033-4"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol035282x"},{"key":"e_1_2_7_33_1","unstructured":"\u00a0"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4GC00013G"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2ra01056a"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20089a"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.05.018"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201602609"},{"key":"e_1_2_7_39_1","unstructured":"\u00a0"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704908"},{"key":"e_1_2_7_40_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201704908"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol1015948"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob26498f"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200900868"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol501024y"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol102664n"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0480848"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo962376u"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b01832"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9016138"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol200957y"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01803"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12628"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja406653n"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00067"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo301234r"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol302355w"},{"key":"e_1_2_7_57_1","unstructured":"\u00a0"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2018.04.012"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200500411"},{"key":"e_1_2_7_60_1","unstructured":"\u00a0"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201501197"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB01679K"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2gc36005e"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol302034r"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1gc00009h"},{"key":"e_1_2_7_66_1","unstructured":"\u00a0"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b01433"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201600138"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41254g"},{"key":"e_1_2_7_70_1","unstructured":"\u00a0"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200800262"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2003.12.117"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol502900j"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39930001001"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.7b02142"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14473"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1515\/znb-2010-0417"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA04293J"},{"key":"e_1_2_7_79_1","unstructured":"\u00a0"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00686-2"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200600519"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-20026"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a007"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-871569"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0104249"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)91094-3"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fasia.201900744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.201900744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.201900744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.201900744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:55:47Z","timestamp":1759942547000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.201900744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":88,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9,16]]}},"alternative-id":["10.1002\/asia.201900744"],"URL":"https:\/\/doi.org\/10.1002\/asia.201900744","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"2019-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}